Family Med Medical News about prevention of cardiovascular mortality;statin treatments

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Mills EJ et al. – Statins have a clear role in primary prevention of cardiovascular disease (CVD) mortality and major events.

Methods

Study to evaluate effectiveness of 3-hydroxy-3-methyl-glutaryl-CoA reductase inhibitors (statins) in primary prevention of cardiovascular events
Comprehensive searches of 10 electronic databases from inception to May 2008
Contact of study investigators for maintainence of a comprehensive bibliography of statin studies
Review of randomized trials of ≥12-mo duration in predominantly primary prevention populations
Independent data extraction in duplicate by 2 reviewers
Random-effects meta-analysis and meta-regression, calculation of optimal information size, and mixed-treatment comparison analysis

Results

Of 20 randomized clinical trials, 19 trials pooled (63,899 pts) for all-cause mortality
Pooled data showed relative risk (RR) of 0.93
Cardiovascular deaths assessed in 18 trials (59,469 pts)
Major cardiovascular events assessed in 17 trials (53,371 pts) with RR of 0.85; 17 trials (52,976 pts) assessed myocardial infarctions
Incidence of cancer not elevated in 10 trials (45,469 pts) nor was rhabdomyolysis
Analysis included a sufficient sample to reliably answer primary outcome of CVD mortality