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Short sleep duration as an independent predictor of cardiovascular events in Japanese patients with hypertension
Archives of Internal Medicine, 11/13/08

Eguchi K et al. – Short sleep duration is associated with incident cardiovascular diseases (CVD) risk; the combination of "the riser pattern" and short sleep duration is most strongly predictive of future CVD, independent of ambulatory blood pressure (BP) levels. Physicians should inquire about sleep duration in risk assessment of hypertensive pts.

Methods

Study of the hypothesis that short sleep duration is independently associated with incident CVD
Ambulatory BP monitoring in 1255 subjects with hypertension
Short sleep duration defined as <7.5 hrs
Riser pattern defined as mean nighttime systolic BP exceeding daytime systolic BP
Endpoint: cardiovascular event of stroke, fatal or nonfatal myocardial infarction (MI), or sudden cardiac death

Results

In multivariable analysss, short sleep duration was associated with incident CVD
Synergistic interaction noted between short sleep duration and the riser pattern
Pts with shorter sleep duration plus the riser pattern had a substantially and significantly higher incidence of CVD than pts with predominant normal sleep duration plus nonriser pattern

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