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Naltrexone for the Treatment of Amphetamine Dependence: A Randomized, Placebo-Controlled Trial
American Journal of Psychiatry, 11/20/08

Jayaram-Lindstrom N et al. - Overall, 55 patients (68.8%) completed the trial. The intention-to-treat analysis showed that the naltrexone group had a significantly higher number of amphetamine-negative urine samples compared with the placebo group. Survival analyses showed that the treatment groups differed in rate of continuous abstinence, in both the intention-to-treat and completer samples, in favor of naltrexone treatment. There was a significant reduction in craving levels and self-reported consumption of amphetamine in the naltrexone group compared with the placebo group. Treatment with naltrexone was well tolerated in this sample.

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