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Do men and women respond differently to blood pressure-lowering treatment? Results of prospectively designed overviews of randomized trials
European Heart Journal, 10/31/08

Turnbull F et al. – All studied blood pressure-lowering regimens offer broadly similar protection against major cardiovascular events in men and women; differences between sexes in cardiovascular risks are unlikely to reflect differences in blood pressure-lowering treatment response

Methods

Overview analyses to quantify effects of blood pressure-lowering treatment in each sex and to determine any important differences in proportional benefits of treatment between men and women
Review of 31 randomized trials of 103,268 men and 87,349 women
Primary outcome: total major cardiovascular events

Results

Achieved blood pressure reductions comparable for men and women in every comparison
No evidence that men and women had different levels of protection from blood pressure lowering
No evidence that regimens based on angiotensin-converting-enzyme inhibitors, calcium antagonists, angiotensin receptor blockers, or diuretics/beta-blockers were more effective for either sex

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