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Alcohol consumption is associated with decreased risk of rheumatoid arthritis; results from two Scandinavian case-control studies
Annals of Rheumatic Diseases, 10/02/08

Källberg H et al. – Recent demonstration of a preventive effect of alcohol in experimental arthritis, indicates that alcohol may protect against rheumatoid arthritis (RA). This highlights the potential role of life-style, and emphasises the advice to stop smoking, but not necessarily to abstain from alcohol in order to diminish risk of RA.

Methods

Study to determine the association between risk of RA and alcohol consumption in combination with smoking and HLA-DRB1 shared epitope (SE)
Data from two independent case-control studies of RA, the Swedish EIRA and the Danish CACORA

Results

Alcohol consumption was, more common in controls and dose-dependently associated with reduced risk of RA in both studies
Among alcohol consumers, the quarter with highest consumption had a decreased risk of RA vs the half with the lowest consumption
For the subset of RA seropositive for abs to citrullinated peptide antigens, alcohol consumption reduced the risk the most in smokers carrying HLA-DRB1 SE alleles

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