The role of cigarette smoking and statins in the development of postmenopausal osteoporosis: A pilot study utilizing the Marshfield Clinic Personalized Medicine Cohort
Giampietro PF et al. – Study provides evidence for a role of genetic variation in interleukin 6 (IL6) and lipoprotein receptor-related protein 5 (LRP5) in conferring risk for osteoporosis in Caucasian women, with the latter manifest only in smokers. Methods- Aim was to assess the relative impact of cigarette smoking, statin use, genetic polymorphisms, and one-way interaction of these factors on development of osteoporosis in postmenopausal women
- Genotyping of 14 SNPs corresponding to:
- vit D receptor gene, estrogen receptor 1,
- collagen type 1 alpha 1, IL6, transcription growth factor beta,
- apolipoprotein E, and LRP5 genes
was performed in cases (n=309) with osteoporosis and controls (n=293) with normal BMD drawn from a homogeneous Caucasian population
- SNPs were chosen based on known functional consequences or prior evidence
- They were genotyped using matrix-assisted laser desorption ionization time-of-flight technology (MALDI TOF)
Results- Cases differed from controls relative to BMI, age, and smoking but not statin use
- After adjusting for age, the IL6 -634G>C (rs1800796) allele showed association with osteoporosis, independent of statin use or smoking status
- On stratification for smoking, association with LRP5 C135242T (rs545382) and osteoporosis emerged, suggestive of potential environmental interaction
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