Association between circulating osteoprogenitor cell numbers and bone mineral density in postmenopausal osteoporosis
Pirro M et al. – Study reports that in postmenopausal osteoporotic women, a reduced number of circulating AP+ cells and increased levels of AP+/CD34+, OCN+, and OCN+/CD34+ cells are associated with reduced bone mineral density (BMD).Methods - Aim was to investigate if an association exists between the number of circulating osteoprogenitor cells and BMD in postmenopausal women with and w/o osteoporosis
- Number of circulating AP+, osteocalcin-positive (OCN+), AP+/CD34+, and OCN+/CD34+ cells was quantified in 54 postmenopausal osteoporotic women and 36 age-matched nonosteoporotic controls
Results - Number of AP+ cells was lower in osteoporotic women
- Higher levels of AP+/CD34+, OCN+, and OCN+/CD34+ cells were found in osteoporotic than controls
- Number of AP+ cells was correlated with lumbar BMD and proximal femur BMD
- Whereas inverse correlations were found between AP+/CD34+ cells, OCN+, OCN+/CD34+, and BMD
- Reduced AP+ cells and increased AP+/CD34?+, OCN+, and OCN+/CD34+ cells were predictors of low BMD, independent of traditional risk factors for osteoporosis
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