Short sleep duration as an independent predictor of cardiovascular events in Japanese patients with hypertension
Eguchi K et al. – Short sleep duration is associated with incident cardiovascular diseases (CVD) risk; the combination of "the riser pattern" and short sleep duration is most strongly predictive of future CVD, independent of ambulatory blood pressure (BP) levels. Physicians should inquire about sleep duration in risk assessment of hypertensive pts. Methods- Study of the hypothesis that short sleep duration is independently associated with incident CVD
- Ambulatory BP monitoring in 1255 subjects with hypertension
- Short sleep duration defined as <7.5 hrs
- Riser pattern defined as mean nighttime systolic BP exceeding daytime systolic BP
- Endpoint: cardiovascular event of stroke, fatal or nonfatal myocardial infarction (MI), or sudden cardiac death
Results- In multivariable analysss, short sleep duration was associated with incident CVD
- Synergistic interaction noted between short sleep duration and the riser pattern
- Pts with shorter sleep duration plus the riser pattern had a substantially and significantly higher incidence of CVD than pts with predominant normal sleep duration plus nonriser pattern
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