Showing Latest Articles
No evidence for human papillomavirus in the etiology of colorectal polyps
Cancer Epidemiology, Biomarkers & Prevention, 08/26/2011
Clinical Article
Burnett–Hartman AN et al. – The findings of this study do not support an etiologic relationship between HPV and colorectal adenomas or hyperplastic polyps; however, the finding suggesting an association between HPV seropositivity and hyperplastic polyps in men may warrant further investigations. After stringent controls for contamination and three methods to assess HPV infection, this study reports no evidence for HPV in the etiology of colorectal neoplasia for either men or women.
Methods- Examined association between oncogenic HPV infection and colorectal polyps
- Case–control study of individuals with colorectal adenomas (n=167), hyperplastic polyps (n=87), and polyp–free controls (n=250)
- Performed real–time PCR for HPV–16 /18 DNA, and SPF PCR covering 43 HPV types, on lesional and normal colorectal tissue samples
- Plasma antibodies for oncogenic HPV types assessed via bead–based multiplex Luminex assay
- HPV DNA was not found in any of the 609 successfully assayed colorectal tissue samples from adenomas, hyperplastic polyps, normal biopsies adjacent to polyps, or normal biopsies of the rectum of disease–free controls
- No association between HPV seropositivity for all oncogenic HPV types combined, for either polyp type, and for men or women
- When analyses were restricted to participants without previous history of polyps, among men [adenomas (n=31), hyperplastic polyps (n=28), and controls (n=68)], there was an association between seropositivity and hyperplastic polyps when all oncogenic HPV types were combined (OR=3.0; 95% CI: 1.1–7.9)
