Statins in prevention and treatment of severe sepsis and septic shock
European Journal of Internal Medicine , 04/04/2011
Kouroumichakis I et al. - This review outlines current evidence on the use of statins for preventing and treating sepsis.
- Severe sepsis is an infection-induced inflammatory syndrome that can lead to multi-organ dysfunction and continues to be a major cause of morbidity and mortality worldwide.
- Selective blocking of inflammatory mediators may be insufficient to arrest the process as numerous cascades are triggered during sepsis and recent therapeutic approaches have proven controversial.
- Statins have a variety of actions that are independent of their lipid lowering effect.
- Their anti-inflammatory, antioxidant, immunomodulatory, and antiapoptotic features have been collectively referred to as pleiotropic effects.
- By virtue of their pleiotropic effects, statins have emerged as potentially useful in various critical care areas such as bacteraemia, the early phases of sepsis and septic shock, as well as the management of serious infections.