Prevalence and correlates of sleep disturbance in systemic sclerosis—Results from the UCLA scleroderma quality of life study
Rheumatology, 02/18/2011
Frech T et al. – This study examines sleep disturbance correlates in patients with SSc. Sleep disturbances are common in SSc and are associated with worsening dyspnoea, depressed mood and severity of reflux symptoms.
Methods- 180 SSc patients
- Observational study
- Completed Medical Outcomes Study Sleep measure (MOS-Sleep scale)
- Patients were administered other patient-reported outcome (PRO) measures including 36-item short form (SF-36), HAQ disability index (HAQ-DI), Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-Fatigue), Center for Epidemiologic Studies Depression (CESD) scale and University of California at Los Angeles Scleroderma Clinical Trial Consortium Gastrointestinal Tract Questionnaire (UCLA SCTC GIT 2.0)
- Descriptive statistics assessed for 6 scales of MOS-Sleep and 9-item sleep problem index (SLP-9; a composite index)
- Computed Spearman’s rank-order correlations between MOS-Sleep scales and HAQ-DI, FACIT-Fatigue, CESD, SSc-SCTC GIT 2.0 and SF-36 scales
- In addition, we developed a regression model to assess predictors of SLP-9 scores
- Covariates included demographics, physician variables of disease severity and patient-reported variables of worsening symptoms and PRO measures
- SSc patients reported a mean (s.d.) of 7.1 (1.73) h of sleep a night
- Patients reported worse scores on 4 of 6 scales (except for snoring and sleep quantity) compared with US general population (P<0.001)
- SLP-9 correlated with worsening pain and dyspnoea over past 1 month, reflux scale of UCLA SCTC GIT 2.0, CESD and FACIT-Fatigue (p 0.26–0.56)
- In stepwise multivariate regression model, CESD, worsening dyspnoea and reflux scale significantly associated with SLP-9 index
