The Role of Benzodiazepines in the Treatment of Anxiety Disorders
Psychiatric Annals, 12/17/2010
Macaluso M et al. – Since the patent of chlordiazepoxide nearly 50 years ago, benzodiazepines are one of the most widely prescribed psychotropic medications worldwide. As a class, benzodiazepines share the following properties: anxiolytic, hypnotic, sedative, anticonvulsant, amnestic, and muscle relaxant. These effects are mediated through agonist activity at GABA–A receptors, where endogenous GABA binding has inhibitory effects.