The bidirectional relationship between headache and chronic musculoskeletal complaints: an 11-year follow-up in the Nord-Trondelag Health Study (HUNT) European Journal of Neurology, 05/15/2012

Hagen K et al. – Chronic musculoskeletal complaints predispose to Chronic daily headache (CDH) and CDH predisposes to chronic musculoskeletal complaints (CMSCs) 11 years later. This may have relevance to understanding the pathophysiology of these disorders. CMSCs should be treated not only to relieve them but also to prevent the development of CDH, and vice versa.

• This longitudinal population-based cohort study used data from two consecutive surveys in the Nord-Trondelag Health Study (HUNT 2 and 3) performed in 1995-1997 and 2006-2008.
• Amongst the 51 383 participants aged ≥ 20 years at baseline, 41 766 were eligible approximately 11 years later.
• Of these, 26 197 (63%) completed the questions regarding headache and CMSCs in HUNT 3.

• A bidirectional relationship was found between headache and CMSCs.
• In the multivariate analyses adjusting for known potential confounders, a nearly twofold risk (OR 1.8; 95% CI 1.5-2.3) for developing CDH was found for those with CMSCs at baseline.
• Vice versa, a similarly elevated risk of CMSCs (OR 1.8; 95% CI 1.2-2.6), and even higher risk of chronic widespread MSCs (OR 2.7; 95% CI 1.6-4.7), was found at follow-up amongst those with CDH at baseline.