Social Cognition and Visual Perception in Schizophrenia Inpatients Treated with First-and Second-Generation Antipsychotic Drugs
Clinical Schizophrenia & Related Psychoses, 04/03/2012

Kucharska–Pietura K et al. – The authors cannot conclude that second–generation antipsychotic drugs (SGAs) were associated with better social cognition than first–generation antipsychotic drugs. However, there were small but significant advantages for SGAs in non–social visual processing function, as evaluated with the Visual Object and Space Perception Test.

• Eighty-four patients completed the Facial Expression Recognition Test, the Voice Emotion Recognition Test, the Short Recognition Memory Test for Faces, and the Reading the Mind in the Eyes Test.
• Patients also completed the Visual Object and Space Perception Test (VOSP) as a control task, which would not engage social cognition.
• The patients were compared with fifty healthy controls matched for age and gender.

• There were no significant differences on social cognitive performance between the FGA- and SGA-treatment groups.
• Nor was olanzapine superior to clozapine, FGAs or both.
• However, patients treated with FGAs performed significantly worse on VOSP compared to both groups treated with SGAs, a 10% difference.