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Combination tiotropium + formoterol superior to tiotropium alone in COPD patients
As reported in Pulmonary Pharmacology & Therapeutics, combination tiotropium (18 mcg) + formoterol (12 mcg) was superior to tiotropium alone in COPD (n=44) patients inadequately controlled with bronchodilator monotherapy. Combination therapy resulted in an increased bronchodilator response (FEV1 and FVC) and a maximum change in FEV1 and FVC over 24 h.
Triple therapy superior to dual therapy in HCV
As reported in Mayo Clinic Proceedings, treatment of hepatitis C virus-infected patients with triple therapy (pegylated-interferon, ribavirin, and teleprevir) is more effective than dual therapy (pegylated-interferon and ribavirin). Specifically, a sustained virologic response was achieved in 51% of treatment-naïve patients, 67% of patients with a prior non-response and 56% of patients with a prior relapse of patients treated with triple therapy compared to 37%, 11%, and 27% of patients treated with dual therapy, respectively.
Green tea reduces BP and improves lipid profile
As reported in Nutrition, Metabolism, and Cardiovascular Diseases, a meta-analysis involved 20 RCTs and 1536 participants showed that consumption of green tea (Camellia sinensis) is associated with a reduction in systolic blood pressure (-1.94 mmHg) and improved lipid profile (TC, -0.13 mmol/l; LDL-C, -0.19 mmol/l). Additional studies quantifying the association are needed.