1Benefit of early statin therapy in patients with acute myocardial infarction who have extremely low low-density lipoprotein cholesterolJACC - Journal of the American College of Cardiology  Full Text  Clinical Article
2Nurse prescribing in general practice: a qualitative study indicates increased job satisfaction and work-related stressFamily Practice  Full Text
3Age-Specific Differences in Outcomes After Out-of-Hospital Cardiac ArrestsPediatrics  Full Text
4Relationship of Maternal Snuff Use and Cigarette Smoking With Neonatal ApneaPediatrics  Full Text
5A prospective cohort study of health behavior profiles after age 50 and mortality riskBMC Public Health  Full Text
6Small proportions of actively-smoking patrons and high PM2.5 levels in southern California tribal casinos: support for smoking bans or designated smoking areasBMC Public Health  Full Text
7A Phase 1 dose-escalation study of the safety and pharmacokinetics of once-daily oral foretinib, a multi-kinase inhibitor, in patients with solid tumorsInvestigational New Drugs  Full Text  Clinical Article
8Incidence and Age-Specific Presentation of Restrictive Eating Disorders in Children: A Canadian Paediatric Surveillance Program Study Archives of Pediatrics and Adolescent Medicine  Full Text
9The short-term effect on alliance and satisfaction of using patient feedback scales in mental health out-patient treatment. A randomised controlled trialBMC Health Services Research  Full Text
10Phase I and pharmacokinetic study of pazopanib and lapatinib combination therapy in patients with advanced solid tumorsInvestigational New Drugs  Full Text  Clinical Article
1NYU study identifies teens at-risk for synthetic marijuana useNew York University News
2First report of its kind examines the burden of mental illness and addictions on Ontario children and youthCentre for Addiction and Mental Health News
3Joslin scientists find direct link between insulin resistance in the brain and behavioral disordersJoslin Diabetes Center News
4Low sugar uptake in brain appears to exacerbate Alzheimer’sUniversity of Southern California Health News
5Medicare slowdown at riskDartmouth-Hitchcock
6In the short run, a high-fat diet may help minimize heart attack damageLoyola University Health System
7‘Feeding and fasting’ hormone adropin can improve insulin actionSaint Louis University Health News
8Episodes of intense anger associated with high risk of heart attack within the next two hoursEuropean Society of Cardiology News
9Appropriate use of aspirin for heart health evaluatedBaylor College of Medicine News
10Genetics at the heart of cardiovascular healthBaylor College of Medicine News

Show Me:

Triple therapy superior to dual therapy in HCV

As reported in Mayo Clinic Proceedings, treatment of hepatitis C virus-infected patients with triple therapy (pegylated-interferon, ribavirin, and teleprevir) is more effective than dual therapy (pegylated-interferon and ribavirin). Specifically, a sustained virologic response was achieved in 51% of treatment-naïve patients, 67% of patients with a prior non-response and 56% of patients with a prior relapse of patients treated with triple therapy compared to 37%, 11%, and 27% of patients treated with dual therapy, respectively.

Tobacco and alcohol use significantly increase risk for ESCC

Based on a meta-analysis (n=5 studies) reported in the American Journal of Gastroenterology, the combined use of tobacco and alcohol increased the risk for esophageal squamous cell carcinoma (OR=3.28) compared with non-users; users of tobacco or alcohol alone had a 20%-30% increased risk of esophageal squamous cell carcinoma compared to non-users.

Predictors of poor coronary collateral circulation in stable CAD

As reported in Angiology, the fasting blood glucose and serum uric acid levels and the white blood cell count were higher in patients with stable CAD (n=480) and associated with poor coronary collateral circulation.

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Clinical Pearls

Clinical Pearl from Smartest DocEin Barium-Ösophagogramm ist zum Nachweis anatomischer Befunde bei symptomatischen Patienten nach einer Anti-Reflux-Operation gut geeignet.

Clinical Pearl from Smartest DocEine Blutdrucksenkung nach Gewichtsverlust lässt sich besser mit einer erhöhten Eiweißzufuhr erhalten.

Clinical Pearl from Smartest DocEin EKG kann die Langzeit-Mortalität bei Patienten mit akuter Herzinsuffizienz prognostizieren.

The Top Read Articles of 2014 are Now Available

Scouring thousands of peer-reviewed journals and popular press, Our Editors just released the Top Read Articles of the Year. See the Top Read List