s-H-FABP levels predict outcome in ICU patients
As reported in Clinical Research in Cardiology, the level of serum heart-type fatty acid-binding protein (s-H-FABP) is higher in ER patients admitted to the ICU than ER patients admitted to other departments. The s-H-FABP level was also higher in ICU non-survivors than ICU survivors. A s-H-FABP level of 20.95 ng/ml had a 81.1% and 66.0% sensitivity and specificity, respectively, for in-hospital mortality.
Tobacco and alcohol use significantly increase risk for ESCC
Based on a meta-analysis (n=5 studies) reported in the American Journal of Gastroenterology, the combined use of tobacco and alcohol increased the risk for esophageal squamous cell carcinoma (OR=3.28) compared with non-users; users of tobacco or alcohol alone had a 20%-30% increased risk of esophageal squamous cell carcinoma compared to non-users.
Triple therapy superior to dual therapy in HCV
As reported in Mayo Clinic Proceedings, treatment of hepatitis C virus-infected patients with triple therapy (pegylated-interferon, ribavirin, and teleprevir) is more effective than dual therapy (pegylated-interferon and ribavirin). Specifically, a sustained virologic response was achieved in 51% of treatment-naïve patients, 67% of patients with a prior non-response and 56% of patients with a prior relapse of patients treated with triple therapy compared to 37%, 11%, and 27% of patients treated with dual therapy, respectively.