Family Medicine - Basic Science/Genetics News & Articles

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Articles

Latest (6) Full Text Articles (306) Focus on Diabetes Mellitus

Ranked, sorted, and summarized by MDLinx editors from the latest literature

Topics:

101 Cidofovir selectivity is based on the different response of normal and cancer cells to DNA damage Full Text BMC Genomics, May 24, 2013

102 A mathematical model of mortality dynamics across the lifespan combining heterogeneity and stochastic effects Experimental Gerontology, May 24, 2013 Review Article

103 Genotype-driven recruitment: a strategy whose time has come? Full Text BMC Genomics, May 24, 2013

104 Focal dermal hypoplasia (goltz-gorlin syndrome): A new case with a novel variant in the PORCN gene (c.1250T>C:p.F417S) and unusual spinal anomaly American Journal of Medical Genetics Part A, May 24, 2013 Review Article

105 Prenatal diagnosis of two fetuses with deletions of 8p23.1, critical region for congenital diaphragmatic hernia and heart defects American Journal of Medical Genetics Part A, May 24, 2013 Review Article

106 Chimerism in monochorionic dizygotic twins: Case study and review American Journal of Medical Genetics Part A, May 24, 2013 Review Article

107 Two is better than one: A case of homozygous myotonic dystrophy type 1 American Journal of Medical Genetics Part A, May 24, 2013 Review Article

108 Lateral meningocele syndrome: Additional report and further evidence supporting a connective tissue basis American Journal of Medical Genetics Part A, May 24, 2013 Review Article

109 Cardiac fat-containing lesions are common in tuberous sclerosis complex American Journal of Medical Genetics Part A, May 24, 2013 Review Article

110 Delineation of a new chromosome 20q11.2 duplication syndrome including the ASXL1 gene American Journal of Medical Genetics Part A, May 24, 2013 Review Article

111 Clinical manifestations of Xq28 functional disomy involving MECP2 in one female and two male patients American Journal of Medical Genetics Part A, May 24, 2013 Review Article

112 Detection of rarely identified multiple mutations in MECP2 gene do not contribute to enhanced severity in rett syndrome American Journal of Medical Genetics Part A, May 24, 2013 Review Article

113 Whole-exome sequencing identified a homozygous FNBP4 mutation in a family with a condition similar to microphthalmia with limb anomalies American Journal of Medical Genetics Part A, May 24, 2013 Review Article

114 Deletion 16p13.11 uncovers NDE1 mutations on the non-deleted homolog and extends the spectrum of severe microcephaly to include fetal brain disruption American Journal of Medical Genetics Part A, May 24, 2013 Review Article

115 Mortality of Congenital Osteochondrodysplasias: A Nationwide Registry-Based Study American Journal of Medical Genetics Part A, May 22, 2013 Review Article

116 Report of a patient with developmental delay, hearing loss, growth retardation, and cleft lip and palate and a deletion of 7q34-36.1: Review of distal 7q deletions American Journal of Medical Genetics Part A, May 22, 2013 Review Article

117 Deletions of 16p11.2 and 19p13.2 in a Family With Intellectual Disability and Generalized Epilepsy American Journal of Medical Genetics Part A, May 22, 2013 Review Article

118 6p25 Microdeletion: White Matter Abnormalities in an Adult Patient American Journal of Medical Genetics Part A, May 22, 2013 Review Article

119 6p21.3 Microdeletion Involving the SYNGAP1 Gene in a Patient With Intellectual Disability, Seizures, and Severe Speech Impairment American Journal of Medical Genetics Part A, May 22, 2013 Review Article

120 Growth hormone receptor (GHR) gene polymorphism and prader-willi syndrome American Journal of Medical Genetics Part A, May 22, 2013 Review Article

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Clinical Pearls in Family Medicine

No relations were found between abdominal adipose tissue and bone mass, fat mass, blood pressure or triglyceride level in overweight adolescents
According to the Cleveland Clinic, the primary risk factors for coronary artery disease (CAD) are diabetes mellitus, family history, hypertension, hyperlipidemia, tobacco use and male gender
Untreated nocturnal gastroesophageal reflux has been demonstrated to be strongly associated with both respiratory and obstructive sleep apnea symptoms as well as airflow obstruction

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Highlights in Family Medicine

Vitamin D supplementation decreases systemic inflammation in T2DM

In a 12-week randomized, controlled trial, ingestion of a vitamin D-fortified yogurt (170 mg calcium + 500 IU vitamin D/250 mL; n=50) twice daily decreased markers of inflammation compared with placebo yogurt (170 mg calcium; n=50). Compared with baseline measures, the 25(OH)D levels were increased and the TNF-alpha, IL-6, hsCRP, SAA, and IL-10 levels were decreased in the group supplemented with vitamin D compared with the group that received placebo.

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Mediterranean diet associated with decreased diabetes, cardiovascular events, and all-cause mortality

Researchers at the University of Palermo conducted a study involving 9109 subjects with a mean follow-up of 6.2 years which showed that the subjects who adhered to a Mediterranean diet had increased dietary fiber, decreased total dietary fat, and an increased intake of monosaturated-to-saturated fats. Further, the incidence of diabetes, cardiovascular events, and all-cause mortality was lower in the subjects who followed a Mediterranean diet.

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Natalizumab superior to IFN-? 1a in MS patients

Based on a retrospective study conducted at the Federico II University (Naples), researchers have concluded that treatment of patients (n=84) with relapsing-remitting MS natalizumab for 12-24 months resulted in a greater reduction in disease activity (annualized relapse rate, .24 vs. .55, respectively) and disability progression than patients treated with INF-? 1a. The number of contrast-enhancing lesions was also less in the natalizumab-treated group.

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Most Popular Family Med Articles

Last month's top read Top Articles of 2012

1 Effects of watermelon supplementation on arterial stiffness and wave reflection amplitude in postmenopausal women Menopause, April 29, 2013

2 Recurrent Pericarditis in Myhre Syndrome American Journal of Medical Genetics Part A, May 1, 2013 Review Article

3 Late and very late coronary stent thrombosis: Intravascular ultrasound findings and associations with anti-platelet therapy Catheterization and Cardiovascular Interventions, May 1, 2013

4 Mechanisms and novel therapeutic approaches of wasting in chronic disease Maturitas, May 1, 2013

5 Carotid artery stenting: Patient, lesion, and procedural characteristics that increase procedural complications Catheterization and Cardiovascular Interventions, May 1, 2013

6 Heart Transplantation and Left Ventricular Assist Device Therapy: Two Comparable Options in End-Stage Heart Failure? Clinical Cardiology, May 1, 2013 Free full text

7 Cis-silencing of PIP5K1B evidenced in Friedreich's ataxia patient cells results in cytoskeleton anomalies Human Molecular Genetics, May 1, 2013 Review Article

8 Models for estimating the biological age of five organs using clinical biomarkers that are commonly measured in clinical practice settings Maturitas, May 1, 2013
Exclusive Author Commentary

9 A novel function of Ataxin-1 in the modulation of PP2A activity is dysregulated in the spinocerebellar ataxia type 1 Human Molecular Genetics, May 8, 2013 Review Article

10 Robust evidence for five new Grave's disease risk loci from a staged genome-wide association analysis Human Molecular Genetics, May 8, 2013 Review Article

11 Intragenic ILRAPL1 Deletion in a Male Patient With Intellectual Disability, Mild Dysmorphic Signs, Deafness, and Behavioral Problems American Journal of Medical Genetics Part A, May 8, 2013 Review Article

12 Machine Learning Prediction of Cancer Cell Sensitivity to Drugs Based on Genomic and Chemical Properties PLOS ONE, May 8, 2013 Review Article

13 Genetic polymorphisms and associated susceptibility to asthma International Journal of General Medicine, May 3, 2013 Free full text

14 12q24.33 Deletion: Report of a Patient With Intellectual Disability and Review of the Literature American Journal of Medical Genetics Part A, May 3, 2013

15 Impaired mitochondrial oxidative phosphorylation in the peroxisomal disease X-linked adrenoleukodystrophy Human Molecular Genetics, May 8, 2013 Review Article

16 Effect of longer term modest salt reduction on blood pressure: Cochrane systematic review and meta-analysis of randomised trials British Medical Journal, April 25, 2013 Evidence Based Medicine Review Article

17 What psychiatric genetics has taught us about the nature of psychiatric illness and what is left to learn Molecular Psychiatry, May 1, 2013 Free full text Review Article

18 Clinical and Genetic Study of a Family With a Paternally Inherited 15q11-q13 Duplication American Journal of Medical Genetics Part A, May 8, 2013 Review Article

19 Impact of age on male fertility Current Opinion in Obstetrics and Gynecology, May 14, 2013 Review Article

20 Effects of insulin and IGF-I on growth hormone- induced STAT5 activation in 3T3-F442A adipocytes Lipids in Health and Disease, May 1, 2013 Free full text

Indexed Journals in Family Medicine: American Family Physician, Archives of Family Med, Annals of Family Med more

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Family Medicine - Basic Science/Genetics News & Articles

Articles

Clinical Pearls in Family Medicine

Highlights in Family Medicine

Vitamin D supplementation decreases systemic inflammation in T2DM

Mediterranean diet associated with decreased diabetes, cardiovascular events, and all-cause mortality

Natalizumab superior to IFN-? 1a in MS patients

Most Popular Family Med Articles

Other Topics in Family Medicine