Family Medicine - Basic Science/Genetics News & Articles

MDLinx Family Medicine stands out from other primary care literature review services because of our dedication to keeping our members current in less time. On a daily basis, receive an email with just the ‘headlines’ covering everything important that published in your specialty in the past 24 hours. Or, choose to Focus On the top articles published in the hottest topics in primary care, such as heart failure, depression, diabetes mellitus, eczema/psoriasis, infectious diseases, rheumatoid arthritis, COPD, and many more.

Additional bonus content is also available on this page, including clinical pearls from The Smartest Family Physician, a daily quiz competition from the editors of MDLinx Internal Medicine in collaboration with the Cleveland Clinic Center for Continuing Education. Additionally, enjoy the can’t-miss articles highlighted by our own physician editor, D. Scott Cunningham, MD, PhD.

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Articles

Latest (3) Full Text Articles (306) Focus on Cancer

Ranked, sorted, and summarized by MDLinx editors from the latest literature

Topics:

41 The genomic landscape of chronic lymphocytic leukemia: clinical implications Full Text BMC Medicine, May 13, 2013

42 Multiple-to-Multiple Relationships between MicroRNAs and Target Genes in Gastric Cancer PLOS ONE, May 13, 2013 Review Article

43 Akt1 Enhances CA916798 Expression through mTOR Pathway PLOS ONE, May 13, 2013 Review Article

44 Co-localisation and secretion of glucagon-like peptide 1 and peptide YY from primary cultured human L cells Diabetologia - Clinical and Experimental Diabetes and Metabolism, May 13, 2013 Review Article

45 Expression of VEGF and Semaphorin Genes Define Subgroups of Triple Negative Breast Cancer PLOS ONE, May 13, 2013 Review Article

46 Oncogenic CSF3R Mutations in Chronic Neutrophilic Leukemia and Atypical CML New England Journal of Medicine, May 13, 2013 Evidence Based Medicine Clinical Article

47 Heralded entanglement between solid-state qubits separated by three metres Nature, May 13, 2013 Review Article

48 Detection of Novel Polyomaviruses, TSPyV, HPyV6, HPyV7, HPyV9 and MWPyV in Feces, Urine, Blood, Respiratory Swabs and Cerebrospinal Fluid PLOS ONE, May 13, 2013 Review Article

49 Phenotypes of Allo- and Autoimmune Antibody Responses to FVIII Characterized by Surface Plasmon Resonance PLOS ONE, May 13, 2013 Review Article

50 Adiponectin Gene Variant Interacts with Fish Oil Supplementation to Influence Serum Adiponectin in Older Individuals The Journal of Nutrition, May 10, 2013 Clinical Article

51 Genetic ancestry modifies the association between genetic risk variants and breast cancer risk among Hispanic and non-Hispanic white women Carcinogenesis, May 10, 2013 Review Article Clinical Article

52 Diagnostic accuracy of HbA1c in diabetes between Eastern and Western European Journal of Clinical Investigation, May 10, 2013 Review Article

53 Somatic Alterations Contributing to Metastasis of a Castration Resistant Prostate Cancer Human Mutation, May 10, 2013 Review Article

54 Early cardiovascular remodelling in Fabry disease Journal of Inherited Metabolic Disease, May 10, 2013 Evidence Based Medicine

55 Elements of Morphology: Standard Terminology for the External Genitalia American Journal of Medical Genetics Part A, May 10, 2013 Review Article

56 Monoamniotic Monochorionic Twins Discordant for Noncompaction Cardiomyopathy American Journal of Medical Genetics Part A, May 10, 2013 Review Article

57 Paternal Inheritance of Classic X-linked Bilateral Periventricular Nodular Heterotopia American Journal of Medical Genetics Part A, May 10, 2013 Review Article

58 Benefits of early development of eye-hand coordination: Evidence from the LOOK longitudinal study Scandinavian Journal of Medicine & Science in Sports, May 10, 2013 Review Article

59 Functional Analysis of a de novo ACTB Mutation in a Patient with Atypical Baraitser-Winter Syndrome Human Mutation, May 10, 2013 Review Article

60 Dissecting the Structure and Mechanism of a Complex Duplication-Triplication Rearrangement in the DMD Gene Human Mutation, May 10, 2013 Review Article

50 available pages First Previous 3 4 5 6 7 8 9 10 11 12 Next Last

Clinical Pearls in Family Medicine

No relations were found between abdominal adipose tissue and bone mass, fat mass, blood pressure or triglyceride level in overweight adolescents
According to the Cleveland Clinic, the primary risk factors for coronary artery disease (CAD) are diabetes mellitus, family history, hypertension, hyperlipidemia, tobacco use and male gender
Untreated nocturnal gastroesophageal reflux has been demonstrated to be strongly associated with both respiratory and obstructive sleep apnea symptoms as well as airflow obstruction

» Test your knowledge. Take the Smartest Doc challenge today!

Highlights in Family Medicine

Vitamin D supplementation decreases systemic inflammation in T2DM

In a 12-week randomized, controlled trial, ingestion of a vitamin D-fortified yogurt (170 mg calcium + 500 IU vitamin D/250 mL; n=50) twice daily decreased markers of inflammation compared with placebo yogurt (170 mg calcium; n=50). Compared with baseline measures, the 25(OH)D levels were increased and the TNF-alpha, IL-6, hsCRP, SAA, and IL-10 levels were decreased in the group supplemented with vitamin D compared with the group that received placebo.

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Mediterranean diet associated with decreased diabetes, cardiovascular events, and all-cause mortality

Researchers at the University of Palermo conducted a study involving 9109 subjects with a mean follow-up of 6.2 years which showed that the subjects who adhered to a Mediterranean diet had increased dietary fiber, decreased total dietary fat, and an increased intake of monosaturated-to-saturated fats. Further, the incidence of diabetes, cardiovascular events, and all-cause mortality was lower in the subjects who followed a Mediterranean diet.

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Natalizumab superior to IFN-? 1a in MS patients

Based on a retrospective study conducted at the Federico II University (Naples), researchers have concluded that treatment of patients (n=84) with relapsing-remitting MS natalizumab for 12-24 months resulted in a greater reduction in disease activity (annualized relapse rate, .24 vs. .55, respectively) and disability progression than patients treated with INF-? 1a. The number of contrast-enhancing lesions was also less in the natalizumab-treated group.

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Most Popular Family Medicine Articles

Last month's top read Top Articles of 2012

1 Prevention of mother-to-child transmission of hepatitis B virus (HBV) during pregnancy and the puerperium: Current standards of care Australian and New Zealand Journal of Obstetrics and Gynaecology, March 6, 2013

2 Cardiovascular events after clarithromycin use in lower respiratory tract infections: analysis of two prospective cohort studies British Medical Journal, April 10, 2013 Free full text

3 Trends in the management and outcome of HIV-1-infected women and their infants in the NISDI Perinatal and LILAC cohorts, 2002-2009 International Journal of Gynecology & Obstetrics, April 10, 2013

4 Safety of Pacemaker Implantation in Nonagenarians Circulation, April 10, 2013

5 Outpatient parenteral antimicrobial therapy British Medical Journal, April 10, 2013

6 Long-Term Survival of Patients With Radiation Heart Disease Undergoing Cardiac Surgery Circulation, April 10, 2013

7 Proton Pump Inhibitors and Risk of 1-Year Mortality and Rehospitalization in Older Patients Discharged From Acute Care Hospitals Proton Pump Inhibitors in Older Patients JAMA Internal Medicine, April 10, 2013

8 Effects of vitamin D supplementation on body fat accumulation, inflammation, and metabolic risk factors in obese adults with low vitamin D levels -- Results from a randomized trial European Journal of Internal Medicine , April 11, 2013

9 Screening for Prostate Cancer: A Guidance Statement From the Clinical Guidelines Committee of the American College of Physicians Annals of Internal Medicine, April 10, 2013 Clinical Guideline

10 Walking Versus Running for Hypertension, Cholesterol, and Diabetes Mellitus Risk Reduction Arteriosclerosis, Thrombosis, and Vascular Biology, April 17, 2013

11 Pharmacologic Therapy for Primary Restless Legs Syndrome A Systematic Review and Meta-analysis Pharmacotherapy for Primary Restless Legs Syndrome JAMA Internal Medicine, April 10, 2013 Evidence Based Medicine Review Article

12 Oral nifedipine versus intravenous labetalol in hypertensive urgencies and emergencies of pregnancy: a randomized clinical trial Obstetric Medicine, April 2, 2013

13 Late Outcomes of Mitral Valve Repair for Mitral Regurgitation Due to Degenerative Disease Circulation, April 10, 2013

14 The Global Cardiovascular Risk Transition Circulation, April 10, 2013

15 Ultrasound imaging for lumbar punctures and epidural catheterisations: systematic review and meta-analysis British Medical Journal, April 10, 2013 Free full text Evidence Based Medicine Review Article

16 Effect of Race and Ethnicity on Outcomes With Drug-Eluting and Bare Metal Stents Circulation, April 10, 2013

17 Effects of imiglucerase on the growth and metabolism of Gaucher disease type I patients: a systematic review Nutrition & Metabolism, April 10, 2013 Free full text Evidence Based Medicine Review Article

18 Coronary artery calcium score prediction of all cause mortality and cardiovascular events in people with type 2 diabetes: systematic review and meta-analysis British Medical Journal, April 10, 2013 Free full text Evidence Based Medicine Review Article

19 Cellular Aging Reflected by Leukocyte Telomere Length Predicts Advanced Atherosclerosis and Cardiovascular Disease Risk Arteriosclerosis, Thrombosis, and Vascular Biology, May 28, 2010

20 Resveratrol regulates human adipocyte number and function in a Sirt1-dependent manner American Journal of Clinical Nutrition, May 27, 2010

Indexed Journals in Family Medicine: American Family Physician, Archives of Family Med, Annals of Family Med more

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Family Medicine - Basic Science/Genetics News & Articles

Articles

Clinical Pearls in Family Medicine

Highlights in Family Medicine

Vitamin D supplementation decreases systemic inflammation in T2DM

Mediterranean diet associated with decreased diabetes, cardiovascular events, and all-cause mortality

Natalizumab superior to IFN-? 1a in MS patients

Most Popular Family Medicine Articles

Other Topics in Family Medicine