Family Medicine - Basic Science/Genetics News & Articles

MDLinx Family Medicine stands out from other primary care literature review services because of our dedication to keeping our members current in less time. On a daily basis, receive an email with just the 'headlines' covering everything important that published in your specialty in the past 24 hours. Or, choose to Focus On the top articles published in the hottest topics in primary care, such as heart failure, depression, diabetes mellitus, eczema/psoriasis, infectious diseases, rheumatoid arthritis, COPD, General Family Medicine News and many more.

Additional bonus content is also available on this page, including clinical pearls from The Smartest Family Physician, a daily quiz competition from the editors of MDLinx Internal Medicine in collaboration with the Cleveland Clinic Center for Continuing Education. Additionally, enjoy the can’t-miss articles highlighted by our own physician editor, D. Scott Cunningham, MD, PhD.

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Articles

Latest (6) Full Text Articles (306) Focus on Diabetes Mellitus

Ranked, sorted, and summarized by MDLinx editors from the latest literature

Topics:

401 Long-Term Safety and Effectiveness of Mechanical Versus Biologic Aortic Valve Prostheses in Older Patients Circulation, April 24, 2013 Clinical Article

402 Utility of established cardiovascular disease risk score models for the 10-year prediction of disease outcomes in women Expert Review of Cardiovascular Therapy , April 24, 2013 Review Article

403 Selection and timing for invasive therapy in non-ST-segment-elevation acute coronary syndrome Expert Review of Cardiovascular Therapy , April 24, 2013 Review Article

404 A comparison of hybrid coronary revascularization and off-pump coronary revascularization Expert Review of Cardiovascular Therapy , April 24, 2013 Review Article

405 Infective Endocarditis New England Journal of Medicine, April 24, 2013 Continuing Medical Education Review Article

406 Perioperative Dexmedetomidine Improves Outcomes of Cardiac Surgery Circulation, April 24, 2013 Clinical Article

407 Treated hypertension and the white coat phenomenon: Office readings are inadequate measures of efficacy Journal of the American Society of Hypertension, April 24, 2013 Clinical Article

408 Fibrinolysis or Primary PCI in ST-Segment Elevation Myocardial Infarction New England Journal of Medicine, April 24, 2013 Continuing Medical Education

409 Telmisartan as a metabolic sartan: The first meta-analysis of randomized controlled trials in metabolic syndrome Journal of the American Society of Hypertension, April 24, 2013 Clinical Article

410 Dose-Adjusted EPOCH-Rituximab Therapy in Primary Mediastinal B-Cell Lymphoma New England Journal of Medicine, April 24, 2013 Clinical Article

411 Giant axonal neuropathy-associated gigaxonin mutations impair intermediate filament protein degradation Full Text The Journal of Clinical Investigation, April 24, 2013 Review Article

412 Sensitization to Cor a 9 and Cor a 14 is highly specific for a hazelnut allergy with objective symptoms in Dutch children and adults The Journal of Allergy and Clinical Immunology, April 24, 2013 Clinical Article

413 Impaired mitochondrial oxidative phosphorylation in the peroxisomal disease X-linked adrenoleukodystrophy Human Molecular Genetics, April 24, 2013 Review Article

414 Impact of disease-causing mutations on TMEM165 subcellular localization, a recently identified protein involved in CDG-II Human Molecular Genetics, April 24, 2013 Review Article

415 Dominant effects of the Huntingtons disease HTT CAG repeat length are captured in gene expression datasets by a continuous analysis mathematical modeling strategy Human Molecular Genetics, April 24, 2013 Review Article

416 A high-content, high-throughput siRNA screen identifies cyclin D2 as a potent regulator of muscle progenitor cell fusion and a target to enhance muscle regeneration Human Molecular Genetics, April 24, 2013 Review Article

417 Patterns and Mutational Signatures of Tandem Base Substitutions Causing Human Inherited Disease Human Mutation, April 24, 2013 Review Article

418 Nutrigenetics and Nutrigenomics of Atherosclerosis Current Atherosclerosis Reports, April 23, 2013 Review Article

419 Predictors of diabetic nephropathy Central European Journal of Medicine, April 23, 2013 Clinical Article

420 Strategy for detection of prostate cancer based on relation between prostate specific antigen at age 40-55 and long term risk of metastasis: case-control study British Medical Journal, April 23, 2013 Clinical Article

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Clinical Pearls in Family Medicine

No relations were found between abdominal adipose tissue and bone mass, fat mass, blood pressure or triglyceride level in overweight adolescents
According to the Cleveland Clinic, the primary risk factors for coronary artery disease (CAD) are diabetes mellitus, family history, hypertension, hyperlipidemia, tobacco use and male gender
Untreated nocturnal gastroesophageal reflux has been demonstrated to be strongly associated with both respiratory and obstructive sleep apnea symptoms as well as airflow obstruction

» Test your knowledge. Take the Smartest Doc challenge today!

Highlights in Family Medicine

Vitamin D supplementation decreases systemic inflammation in T2DM

In a 12-week randomized, controlled trial, ingestion of a vitamin D-fortified yogurt (170 mg calcium + 500 IU vitamin D/250 mL; n=50) twice daily decreased markers of inflammation compared with placebo yogurt (170 mg calcium; n=50). Compared with baseline measures, the 25(OH)D levels were increased and the TNF-alpha, IL-6, hsCRP, SAA, and IL-10 levels were decreased in the group supplemented with vitamin D compared with the group that received placebo.

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Mediterranean diet associated with decreased diabetes, cardiovascular events, and all-cause mortality

Researchers at the University of Palermo conducted a study involving 9109 subjects with a mean follow-up of 6.2 years which showed that the subjects who adhered to a Mediterranean diet had increased dietary fiber, decreased total dietary fat, and an increased intake of monosaturated-to-saturated fats. Further, the incidence of diabetes, cardiovascular events, and all-cause mortality was lower in the subjects who followed a Mediterranean diet.

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Natalizumab superior to IFN-? 1a in MS patients

Based on a retrospective study conducted at the Federico II University (Naples), researchers have concluded that treatment of patients (n=84) with relapsing-remitting MS natalizumab for 12-24 months resulted in a greater reduction in disease activity (annualized relapse rate, .24 vs. .55, respectively) and disability progression than patients treated with INF-? 1a. The number of contrast-enhancing lesions was also less in the natalizumab-treated group.

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Most Popular Family Med Articles

Last month's top read Top Articles of 2012

1 Effects of watermelon supplementation on arterial stiffness and wave reflection amplitude in postmenopausal women Menopause, April 29, 2013

2 Recurrent Pericarditis in Myhre Syndrome American Journal of Medical Genetics Part A, May 1, 2013 Review Article

3 Late and very late coronary stent thrombosis: Intravascular ultrasound findings and associations with anti-platelet therapy Catheterization and Cardiovascular Interventions, May 1, 2013

4 Mechanisms and novel therapeutic approaches of wasting in chronic disease Maturitas, May 1, 2013

5 Carotid artery stenting: Patient, lesion, and procedural characteristics that increase procedural complications Catheterization and Cardiovascular Interventions, May 1, 2013

6 Heart Transplantation and Left Ventricular Assist Device Therapy: Two Comparable Options in End-Stage Heart Failure? Clinical Cardiology, May 1, 2013 Free full text

7 Cis-silencing of PIP5K1B evidenced in Friedreich's ataxia patient cells results in cytoskeleton anomalies Human Molecular Genetics, May 1, 2013 Review Article

8 Models for estimating the biological age of five organs using clinical biomarkers that are commonly measured in clinical practice settings Maturitas, May 1, 2013
Exclusive Author Commentary

9 A novel function of Ataxin-1 in the modulation of PP2A activity is dysregulated in the spinocerebellar ataxia type 1 Human Molecular Genetics, May 8, 2013 Review Article

10 Robust evidence for five new Grave's disease risk loci from a staged genome-wide association analysis Human Molecular Genetics, May 8, 2013 Review Article

11 Intragenic ILRAPL1 Deletion in a Male Patient With Intellectual Disability, Mild Dysmorphic Signs, Deafness, and Behavioral Problems American Journal of Medical Genetics Part A, May 8, 2013 Review Article

12 Machine Learning Prediction of Cancer Cell Sensitivity to Drugs Based on Genomic and Chemical Properties PLOS ONE, May 8, 2013 Review Article

13 Genetic polymorphisms and associated susceptibility to asthma International Journal of General Medicine, May 3, 2013 Free full text

14 12q24.33 Deletion: Report of a Patient With Intellectual Disability and Review of the Literature American Journal of Medical Genetics Part A, May 3, 2013

15 Impaired mitochondrial oxidative phosphorylation in the peroxisomal disease X-linked adrenoleukodystrophy Human Molecular Genetics, May 8, 2013 Review Article

16 Effect of longer term modest salt reduction on blood pressure: Cochrane systematic review and meta-analysis of randomised trials British Medical Journal, April 25, 2013 Evidence Based Medicine Review Article

17 What psychiatric genetics has taught us about the nature of psychiatric illness and what is left to learn Molecular Psychiatry, May 1, 2013 Free full text Review Article

18 Clinical and Genetic Study of a Family With a Paternally Inherited 15q11-q13 Duplication American Journal of Medical Genetics Part A, May 8, 2013 Review Article

19 Impact of age on male fertility Current Opinion in Obstetrics and Gynecology, May 14, 2013 Review Article

20 Effects of insulin and IGF-I on growth hormone- induced STAT5 activation in 3T3-F442A adipocytes Lipids in Health and Disease, May 1, 2013 Free full text

Indexed Journals in Family Medicine: American Family Physician, Archives of Family Med, Annals of Family Med more

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Family Medicine - Basic Science/Genetics News & Articles

Articles

Clinical Pearls in Family Medicine

Highlights in Family Medicine

Vitamin D supplementation decreases systemic inflammation in T2DM

Mediterranean diet associated with decreased diabetes, cardiovascular events, and all-cause mortality

Natalizumab superior to IFN-? 1a in MS patients

Most Popular Family Med Articles

Other Topics in Family Medicine