Family Medicine - Clinical Pharmacology News & Articles

MDLinx Family Medicine stands out from other primary care literature review services because of our dedication to keeping our members current in less time. On a daily basis, receive an email with just the ‘headlines’ covering everything important that published in your specialty in the past 24 hours. Or, choose to Focus On the top articles published in the hottest topics in primary care, such as heart failure, depression, diabetes mellitus, eczema/psoriasis, infectious diseases, rheumatoid arthritis, COPD, and many more.

Additional bonus content is also available on this page, including clinical pearls from The Smartest Family Physician, a daily quiz competition from the editors of MDLinx Internal Medicine in collaboration with the Cleveland Clinic Center for Continuing Education. Additionally, enjoy the can’t-miss articles highlighted by our own physician editor, D. Scott Cunningham, MD, PhD.

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Articles

Latest (21) Full Text Articles (829) Focus on Anxiety Disorders

Ranked, sorted, and summarized by MDLinx editors from the latest literature

Topics:

81 Clinical features and outcome of leptomeningeal metastasis in patients with breast cancer: a single center experience Cancer Chemotherapy and Pharmacology, May 14, 2013 Clinical Article

82 Profile of once-daily zonisamide as monotherapy for treatment of partial seizures in adults Full Text Drug Design, Development and Therapy, May 14, 2013 Review Article

83 Recommendations for the emergency management of complications associated with the new direct oral anticoagulants (DOACs), apixaban, dabigatran and rivaroxaban Clinical Research in Cardiology, May 14, 2013 Clinical Article

84 The effect of topiramate on weight loss in patients with type 2 diabetes Journal of Research in Medical Sciences, May 14, 2013 Evidence Based Medicine Clinical Article

85 Can Statins Improve Outcomes After Isolated Cardiac Valve Surgery? A Systematic Literature Review Full Text Clinical Cardiology, May 14, 2013 Evidence Based Medicine Review Article

86 Effects of long-term use of clonazepam on nonrapid eye movement sleep patterns in rapid eye movement sleep behavior disorder Sleep Medicine, May 14, 2013 Clinical Article

87 Concurrent sunitinib and stereotactic body radiotherapy for patients with oligometastases Targeted Oncology, May 14, 2013 Clinical Article

88 Rutosides for treatment of post-thrombotic syndrome Cochrane Reviews, May 14, 2013 Evidence Based Medicine Clinical Article

89 Levodopa changes the severity of freezing in Parkinsons disease Parkinsonism & Related Disorders, May 14, 2013 Clinical Article

90 Effect of a Novel Calcium Channel Blocker on Abnormal Nocturnal Blood Pressure in Hypertensive Patients The Journal of Clinical Hypertension, May 13, 2013 Clinical Article

91 New Oral Anticoagulants in Non-Valvular Atrial Fibrillation High Blood Pressure & Cardiovascular Prevention, May 13, 2013 Clinical Article

92 Low-dose propranolol and exercise capacity in postural tachycardia syndrome: A randomized study Neurology, May 13, 2013 Clinical Article

93 Antihypertensive Response to Combination of Olmesartan and Amlodipine Does Not Depend on Method and Time of Drug Administration High Blood Pressure & Cardiovascular Prevention, May 13, 2013 Clinical Article

94 Levomepromazine for nausea and vomiting in palliative care Cochrane Reviews, May 13, 2013 Evidence Based Medicine Clinical Article

95 Sulphonylurea monotherapy for patients with type 2 diabetes mellitus Cochrane Reviews, May 13, 2013 Evidence Based Medicine Clinical Article

96 The New Oral Anticoagulants in Clinical Practice Mayo Clinic Proceedings, May 13, 2013 Clinical Article

97 Rutosides for prevention of post-thrombotic syndrome Cochrane Reviews, May 13, 2013 Clinical Article

98 Mortality outcomes of different sulfonylurea drugs. The results of a 14-year cohort study of type 2 diabetic patients European Journal of Endocrinology, May 13, 2013 Clinical Article

99 Ranibizumab: The First Vascular Endothelial Growth Factor Inhibitor Approved for the Treatment of Diabetic Macular Edema Annals of Pharmacotherapy, May 13, 2013 Review Article

100 Delayed antibiotics for respiratory infections Cochrane Reviews, May 13, 2013 Evidence Based Medicine Clinical Article

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Clinical Pearls in Family Medicine

No relations were found between abdominal adipose tissue and bone mass, fat mass, blood pressure or triglyceride level in overweight adolescents
According to the Cleveland Clinic, the primary risk factors for coronary artery disease (CAD) are diabetes mellitus, family history, hypertension, hyperlipidemia, tobacco use and male gender
Untreated nocturnal gastroesophageal reflux has been demonstrated to be strongly associated with both respiratory and obstructive sleep apnea symptoms as well as airflow obstruction

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Highlights in Family Medicine

Vitamin D supplementation decreases systemic inflammation in T2DM

In a 12-week randomized, controlled trial, ingestion of a vitamin D-fortified yogurt (170 mg calcium + 500 IU vitamin D/250 mL; n=50) twice daily decreased markers of inflammation compared with placebo yogurt (170 mg calcium; n=50). Compared with baseline measures, the 25(OH)D levels were increased and the TNF-alpha, IL-6, hsCRP, SAA, and IL-10 levels were decreased in the group supplemented with vitamin D compared with the group that received placebo.

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Mediterranean diet associated with decreased diabetes, cardiovascular events, and all-cause mortality

Researchers at the University of Palermo conducted a study involving 9109 subjects with a mean follow-up of 6.2 years which showed that the subjects who adhered to a Mediterranean diet had increased dietary fiber, decreased total dietary fat, and an increased intake of monosaturated-to-saturated fats. Further, the incidence of diabetes, cardiovascular events, and all-cause mortality was lower in the subjects who followed a Mediterranean diet.

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Natalizumab superior to IFN-? 1a in MS patients

Based on a retrospective study conducted at the Federico II University (Naples), researchers have concluded that treatment of patients (n=84) with relapsing-remitting MS natalizumab for 12-24 months resulted in a greater reduction in disease activity (annualized relapse rate, .24 vs. .55, respectively) and disability progression than patients treated with INF-? 1a. The number of contrast-enhancing lesions was also less in the natalizumab-treated group.

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Most Popular Family Medicine Articles

Last month's top read Top Articles of 2012

1 The Importance of 24-Hour Ambulatory Blood Pressure Monitoring in Patients at Risk of Cardiovascular Events High Blood Pressure & Cardiovascular Prevention, April 16, 2013

2 Oral nifedipine versus intravenous labetalol in hypertensive urgencies and emergencies of pregnancy: a randomized clinical trial Obstetric Medicine, April 2, 2013

3 Role of Ambulatory Blood Pressure Monitoring in Hypertension and Diabetes Current Hypertension Reports, April 19, 2013

4 Prolonged febrile seizures, clinical characteristics, and acute management Epilepsia, April 5, 2013

5 Osteoarthritis guidelines: a progressive role for topical nonsteroidal anti-inflammatory drugs Journal of Multidisciplinary Healthcare, April 4, 2013 Review Article Clinical Guideline

6 Meta-Analysis of Impact of Different Types and Doses of Statins on New-Onset Diabetes Mellitus The American Journal of Cardiology, April 4, 2013 Evidence Based Medicine Review Article

7 Cancer Immunotherapy: Present Status, Future Perspective, and a New Paradigm of Peptide Immunotherapeutics Discovery Medicine, April 1, 2013 Free full text Review Article

8 Corticosteroids for preventing postherpetic neuralgia Cochrane Reviews, April 2, 2013 Evidence Based Medicine

9 Vitamin D Levels for Preventing Acute Coronary Syndrome and Mortality: Evidence of a Non-Linear Association Journal of Clinical Endocrinology and Metabolism, March 27, 2013
Exclusive Author Commentary

10 Systematic review: pentoxifylline for the treatment of severe alcoholic hepatitis Alimentary Pharmacology and Therapeutics, April 3, 2013 Review Article

11 Association between maternal serum 25-hydroxyvitamin D level and pregnancy and neonatal outcomes: systematic review and meta-analysis of observational studies British Medical Journal, April 10, 2013 Free full text Review Article

12 HDL and Cholesterol: Life after the divorce? Journal of Lipid Research, March 26, 2013 Review Article

13 Branded Versus Generic Clopidogrel in Cardiovascular Diseases: A Systematic Review Journal of Cardiovascular Pharmacology, April 15, 2013 Evidence Based Medicine Review Article

14 Risk-Benefit Profile of Warfarin Versus Aspirin in Patients With Heart Failure and Sinus Rhythm: A Meta-analysis Circulation: Heart Failure, April 3, 2013 Evidence Based Medicine Review Article

15 A Possible New Option for Migraine Management: Agomelatine Clinical Neuropharmacology, April 3, 2013

16 Hypertension and antihypertensive drugs in pregnancy and perinatal outcomes American Journal of Obstetrics and Gynecology, April 15, 2013

17 In-treatment HDL cholesterol levels and development of new diabetes mellitus in hypertensive patients: The LIFE Study Diabetic Medicine, April 18, 2013

18 Antihypertensive treatment in diabetic patients- Review of current data Maturitas, April 15, 2013 Review Article

19 Update on the Antimicrobial Management of Foot Infections in Patients With Diabetes Clinical Diabetes, April 18, 2013 Free full text Review Article

20 Evidence for Therapeutic Uses of Nebulized Lidocaine in the Treatment of Intractable Cough and Asthma Annals of Pharmacotherapy, April 10, 2013 Review Article

Indexed Journals in Family Medicine: American Family Physician, Archives of Family Med, Annals of Family Med more

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Family Medicine - Clinical Pharmacology News & Articles

Articles

Clinical Pearls in Family Medicine

Highlights in Family Medicine

Vitamin D supplementation decreases systemic inflammation in T2DM

Mediterranean diet associated with decreased diabetes, cardiovascular events, and all-cause mortality

Natalizumab superior to IFN-? 1a in MS patients

Most Popular Family Medicine Articles

Other Topics in Family Medicine