Family Medicine - Clinical Pharmacology News & Articles

MDLinx Family Medicine stands out from other primary care literature review services because of our dedication to keeping our members current in less time. On a daily basis, receive an email with just the ‘headlines’ covering everything important that published in your specialty in the past 24 hours. Or, choose to Focus On the top articles published in the hottest topics in primary care, such as heart failure, depression, diabetes mellitus, eczema/psoriasis, infectious diseases, rheumatoid arthritis, COPD, and many more.

Additional bonus content is also available on this page, including clinical pearls from The Smartest Family Physician, a daily quiz competition from the editors of MDLinx Internal Medicine in collaboration with the Cleveland Clinic Center for Continuing Education. Additionally, enjoy the can’t-miss articles highlighted by our own physician editor, D. Scott Cunningham, MD, PhD.

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Articles

Latest (21) Full Text Articles (829) Focus on Anxiety Disorders

Ranked, sorted, and summarized by MDLinx editors from the latest literature

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41 Risk of hypertension in cancer patients treated with sorafenib: an updated systematic review and meta-analysis Journal of Human Hypertension, May 20, 2013 Evidence Based Medicine Review Article Clinical Article

42 Triple Therapy With Aspirin, Prasugrel, and Vitamin K Antagonists in Patients With Drug-Eluting Stent Implantation and an Indication for Oral Anticoagulation JACC - Journal of the American College of Cardiology, May 20, 2013 Clinical Article

43 Liraglutide suppresses postprandial triglyceride and apolipoprotein B48 elevations after a fat-rich meal in patients with type 2 diabetes: A randomized, double-blind, placebo-controlled, crossover trial Diabetes, Obesity and Metabolism, May 20, 2013 Clinical Article

44 Adalimumab in active ulcerative colitis: A real-life observational study Digestive and Liver Diseases, May 20, 2013 Clinical Article

45 A 6 month, prospective, observational study of PDE5 inhibitor treatment persistence and adherence in Latin American men with erectile dysfunction Current Medical Research and Opinion, May 20, 2013 Clinical Article

46 Esomeprazole and aspirin fixed combination for the prevention of cardiovascular events Full Text Vascular Health and Risk Management, May 20, 2013 Clinical Article

47 The Effect of the Endothelin-1 Receptor Antagonist, Bosentan, on Patients with Poorly Controlled Asthma: A 17-week, Double-Blind, Placebo-Controlled Crossover Pilot Study Journal of Asthma, May 20, 2013 Clinical Article

48 Phase I dose-escalation study and population pharmacokinetic analysis of fixed dose rate gemcitabine plus carboplatin as second-line therapy in patients with ovarian cancer Gynecologic Oncology, May 20, 2013 Clinical Article

49 Phase II study of temsirolimus (CCI-779) in women with recurrent, unresectable, locally advanced or metastatic carcinoma of the cervix. a trial of the NCIC clinical trials group (NCIC CTG IND 199) Gynecologic Oncology, May 20, 2013 Clinical Article

50 Gemcitabine, oxaliplatin and dexamethasone as salvage treatment for elderly patients with refractory and relapsed peripheral T-cell lymphoma Leukemia and Lymphoma, May 20, 2013 Clinical Article

51 Effect of Formoterol on Eosinophil Trans-Basement Membrane Migration Induced by Interleukin-8-Stimulated Neutrophils International Archives of Allergy and Immunology, May 20, 2013 Clinical Article

52 Comparing nilotinib with dasatinib as second-line therapies in patients with chronic myelogenous leukemia resistant or intolerant to imatinib a retrospective chart review analysis Current Medical Research and Opinion, May 20, 2013 Review Article

53 Prescription Opioids for Back Pain and Use of Medications for Erectile Dysfunction Spine, May 17, 2013 Evidence Based Medicine Clinical Article

54 Adulterated Sexual Enhancement Supplements: More Than Mojo JAMA Internal Medicine, May 17, 2013 Review Article Clinical Article

55 Cost-Effectiveness of Duloxetine in Chronic Low Back Pain: A Quebec Societal Perspective Spine, May 17, 2013 Evidence Based Medicine Clinical Article

56 Spinal Injection Therapy for Low Back Pain JAMA, May 17, 2013 Clinical Article

57 A dose-ranging study of cabozantinib in men with castration-resistant prostate cancer and bone metastases Clinical Cancer Research, May 17, 2013 Clinical Article

58 Influence of compliance on bone mineral density changes in postmenopausal women with early breast cancer on Anastrozole Journal of Cancer Research & Clinical Oncology, May 17, 2013 Clinical Article

59 Triple therapy with deferiprone, idebenone and riboflavin in Friedreich's ataxia – open-label trial Acta Neurologica Scandinavica, May 17, 2013 Clinical Article

60 Targeted use of heparin, heparinoids, or low-molecular-weight heparin to improve outcome after acute ischaemic stroke: an individual patient data meta-analysis of randomised controlled trials The Lancet Neurology, May 17, 2013 Evidence Based Medicine Review Article Clinical Article

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Clinical Pearls in Family Medicine

No relations were found between abdominal adipose tissue and bone mass, fat mass, blood pressure or triglyceride level in overweight adolescents
According to the Cleveland Clinic, the primary risk factors for coronary artery disease (CAD) are diabetes mellitus, family history, hypertension, hyperlipidemia, tobacco use and male gender
Untreated nocturnal gastroesophageal reflux has been demonstrated to be strongly associated with both respiratory and obstructive sleep apnea symptoms as well as airflow obstruction

» Test your knowledge. Take the Smartest Doc challenge today!

Highlights in Family Medicine

Vitamin D supplementation decreases systemic inflammation in T2DM

In a 12-week randomized, controlled trial, ingestion of a vitamin D-fortified yogurt (170 mg calcium + 500 IU vitamin D/250 mL; n=50) twice daily decreased markers of inflammation compared with placebo yogurt (170 mg calcium; n=50). Compared with baseline measures, the 25(OH)D levels were increased and the TNF-alpha, IL-6, hsCRP, SAA, and IL-10 levels were decreased in the group supplemented with vitamin D compared with the group that received placebo.

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Mediterranean diet associated with decreased diabetes, cardiovascular events, and all-cause mortality

Researchers at the University of Palermo conducted a study involving 9109 subjects with a mean follow-up of 6.2 years which showed that the subjects who adhered to a Mediterranean diet had increased dietary fiber, decreased total dietary fat, and an increased intake of monosaturated-to-saturated fats. Further, the incidence of diabetes, cardiovascular events, and all-cause mortality was lower in the subjects who followed a Mediterranean diet.

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Natalizumab superior to IFN-? 1a in MS patients

Based on a retrospective study conducted at the Federico II University (Naples), researchers have concluded that treatment of patients (n=84) with relapsing-remitting MS natalizumab for 12-24 months resulted in a greater reduction in disease activity (annualized relapse rate, .24 vs. .55, respectively) and disability progression than patients treated with INF-? 1a. The number of contrast-enhancing lesions was also less in the natalizumab-treated group.

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Most Popular Family Medicine Articles

Last month's top read Top Articles of 2012

1 The Importance of 24-Hour Ambulatory Blood Pressure Monitoring in Patients at Risk of Cardiovascular Events High Blood Pressure & Cardiovascular Prevention, April 16, 2013

2 Oral nifedipine versus intravenous labetalol in hypertensive urgencies and emergencies of pregnancy: a randomized clinical trial Obstetric Medicine, April 2, 2013

3 Role of Ambulatory Blood Pressure Monitoring in Hypertension and Diabetes Current Hypertension Reports, April 19, 2013

4 Prolonged febrile seizures, clinical characteristics, and acute management Epilepsia, April 5, 2013

5 Osteoarthritis guidelines: a progressive role for topical nonsteroidal anti-inflammatory drugs Journal of Multidisciplinary Healthcare, April 4, 2013 Review Article Clinical Guideline

6 Meta-Analysis of Impact of Different Types and Doses of Statins on New-Onset Diabetes Mellitus The American Journal of Cardiology, April 4, 2013 Evidence Based Medicine Review Article

7 Cancer Immunotherapy: Present Status, Future Perspective, and a New Paradigm of Peptide Immunotherapeutics Discovery Medicine, April 1, 2013 Free full text Review Article

8 Corticosteroids for preventing postherpetic neuralgia Cochrane Reviews, April 2, 2013 Evidence Based Medicine

9 Vitamin D Levels for Preventing Acute Coronary Syndrome and Mortality: Evidence of a Non-Linear Association Journal of Clinical Endocrinology and Metabolism, March 27, 2013
Exclusive Author Commentary

10 Systematic review: pentoxifylline for the treatment of severe alcoholic hepatitis Alimentary Pharmacology and Therapeutics, April 3, 2013 Review Article

11 Association between maternal serum 25-hydroxyvitamin D level and pregnancy and neonatal outcomes: systematic review and meta-analysis of observational studies British Medical Journal, April 10, 2013 Free full text Review Article

12 HDL and Cholesterol: Life after the divorce? Journal of Lipid Research, March 26, 2013 Review Article

13 Branded Versus Generic Clopidogrel in Cardiovascular Diseases: A Systematic Review Journal of Cardiovascular Pharmacology, April 15, 2013 Evidence Based Medicine Review Article

14 Risk-Benefit Profile of Warfarin Versus Aspirin in Patients With Heart Failure and Sinus Rhythm: A Meta-analysis Circulation: Heart Failure, April 3, 2013 Evidence Based Medicine Review Article

15 A Possible New Option for Migraine Management: Agomelatine Clinical Neuropharmacology, April 3, 2013

16 Hypertension and antihypertensive drugs in pregnancy and perinatal outcomes American Journal of Obstetrics and Gynecology, April 15, 2013

17 In-treatment HDL cholesterol levels and development of new diabetes mellitus in hypertensive patients: The LIFE Study Diabetic Medicine, April 18, 2013

18 Antihypertensive treatment in diabetic patients- Review of current data Maturitas, April 15, 2013 Review Article

19 Update on the Antimicrobial Management of Foot Infections in Patients With Diabetes Clinical Diabetes, April 18, 2013 Free full text Review Article

20 Evidence for Therapeutic Uses of Nebulized Lidocaine in the Treatment of Intractable Cough and Asthma Annals of Pharmacotherapy, April 10, 2013 Review Article

Indexed Journals in Family Medicine: American Family Physician, Archives of Family Med, Annals of Family Med more

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Family Medicine - Clinical Pharmacology News & Articles

Articles

Clinical Pearls in Family Medicine

Highlights in Family Medicine

Vitamin D supplementation decreases systemic inflammation in T2DM

Mediterranean diet associated with decreased diabetes, cardiovascular events, and all-cause mortality

Natalizumab superior to IFN-? 1a in MS patients

Most Popular Family Medicine Articles

Other Topics in Family Medicine