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Ranked, sorted, and summarized by MDLinx editors from the latest literature

1 Dutasteride plus Tamsulosin fixed-dose combination first-line therapy versus Tamsulosin Monotherapy in the treatment of benign prostatic hyperplasia: A budget impact analysis in the Greek healthcare setting Full Text BMC Urology, October 1, 2014    Clinical Article

2 Effectiveness of cognitive behavioural therapy for anxiety and depression in primary care: A meta-analysis Family Practice, October 1, 2014    Evidence Based Medicine

3 Hospital admissions after transrectal ultrasound-guided biopsy of the prostate in men diagnosed with prostate cancer: A database analysis in England International Journal of Urology, October 1, 2014    Clinical Article

4 Subjective cognitive concerns and neuropsychiatric predictors of progression to the early clinical stages of Alzheimer disease The American Journal of Geriatric Psychiatry, October 1, 2014    Clinical Article

5 Nutritional interventions for the adjunctive treatment of schizophrenia: A brief review Full Text Nutrition Journal, October 1, 2014    Review Article

6 Comparative analysis of monoclonal antibodies against prostate-specific membrane antigen (PSMA) The Prostate, October 1, 2014    Clinical Article

7 Neuropsychiatric systemic lupus erythematosus: pathogenesis and biomarkers Nature Reviews Neurology, October 1, 2014    Review Article

8 Response and remission rates with adjunctive aripiprazole in patients with major depressive disorder who exhibit minimal or no improvement on antidepressant monotherapy International Journal of Clinical Practice, October 1, 2014    Clinical Article

9 Psychosocial factors modify the association of frailty with adverse outcomes: a prospective study of hospitalised older people Full Text BMC Geriatrics, October 1, 2014    Clinical Article

10 Prediction of Parkinson's disease subsequent to severe depression: a ten-year follow-up study Journal of Neural Transmission, October 1, 2014    Clinical Article

11 Antidepressant treatment and suicide attempts and self-inflicted injury in children and adolescents Pharmacoepidemiology and Drug Safety, October 1, 2014    Clinical Article

12 Relationships between obesity management and depression management in a university-based family medicine center Journal of the American Academy of Nurse Practitioners, October 1, 2014    Clinical Article

13 The effect of recent bereavement on outcomes in a primary care depression intervention study The American Journal of Geriatric Psychiatry, October 1, 2014    Clinical Article

14 5α-Reductase inhibitor is less effective in men with small prostate volume and low serum prostatic specific antigen level Journal of the Formosan Medical Association, October 1, 2014    Clinical Article

15 8q24 risk alleles and prostate cancer in African-Barbadian men The Prostate, October 1, 2014    Clinical Article

16 Comparing Engage with PST in late-life major depression: A preliminary report The American Journal of Geriatric Psychiatry, October 1, 2014    Clinical Article

17 A prospective study of depression and anxiety in female fertility preservation and infertility patients Fertility and Sterility, October 1, 2014    Clinical Article

18 Alcohol consumption patterns and cognitive impairment in older women The American Journal of Geriatric Psychiatry, October 1, 2014    Clinical Article

19 Evidence for progressive brain abnormalities in early schizophrenia: A cross-sectional structural and functional connectivity study Schizophrenia Research, October 1, 2014    Clinical Article

20 Youth mental health in deprived urban areas: a Delphi study on the role of the GP in early intervention Irish Journal of Medical Science, October 1, 2014    Review Article

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Highlights in Family Medicine

Triple therapy superior to dual therapy in HCV

As reported in Mayo Clinic Proceedings, treatment of hepatitis C virus-infected patients with triple therapy (pegylated-interferon, ribavirin, and teleprevir) is more effective than dual therapy (pegylated-interferon and ribavirin). Specifically, a sustained virologic response was achieved in 51% of treatment-naïve patients, 67% of patients with a prior non-response and 56% of patients with a prior relapse of patients treated with triple therapy compared to 37%, 11%, and 27% of patients treated with dual therapy, respectively.

Combination tiotropium + formoterol superior to tiotropium alone in COPD patients

As reported in Pulmonary Pharmacology & Therapeutics, combination tiotropium (18 mcg) + formoterol (12 mcg) was superior to tiotropium alone in COPD (n=44) patients inadequately controlled with bronchodilator monotherapy. Combination therapy resulted in an increased bronchodilator response (FEV1 and FVC) and a maximum change in FEV1 and FVC over 24 h.

Tobacco and alcohol use significantly increase risk for ESCC

Based on a meta-analysis (n=5 studies) reported in the American Journal of Gastroenterology, the combined use of tobacco and alcohol increased the risk for esophageal squamous cell carcinoma (OR=3.28) compared with non-users; users of tobacco or alcohol alone had a 20%-30% increased risk of esophageal squamous cell carcinoma compared to non-users.

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