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1 Can unipolar and bipolar pediatric major depression be differentiated from each other?: A systematic review of cross-sectional studies examining differences in unipolar and bipolar depression Journal of Affective Disorders, January 30, 2015    Evidence Based Medicine

2 The role of magnetic resonance image-guided prostate biopsy in stratifying men for risk of extracapsular extension at radical prostatectomy The Journal of Urology, January 30, 2015    Clinical Article

3 Sexually transmitted infections, benign prostatic hyperplasia and lower urinary tract symptom-related outcomes: Results from the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial BJU International, January 30, 2015    Clinical Article

4 The elevated C-reactive protein level is associated with poor prognosis in prostate cancer patients treated European Journal of Cancer, January 30, 2015    Clinical Article

5 Validation studies of the Edinburgh Postnatal Depression Scale for the antenatal period Journal of Affective Disorders, January 30, 2015    Review Article

6 The primary local stage at diagnosis predicts regional symptoms caused by local progression in patients with castration-resistant prostate cancer Urology, January 30, 2015    Clinical Article

7 Causes of death in men with localised prostate cancer: A nationwide, population-based study BJU International, January 30, 2015    Clinical Article

8 Central obesity is predictive of persistent storage LUTS after surgery for Benign Prostatic Enlargement: Results of a multicenter prospective study BJU International, January 30, 2015    Clinical Article

9 A prospective cohort study of depression in pregnancy, prevalence and risk factors in a multi-ethnic population Full Text BMC Pregnancy and Childbirth, January 30, 2015    Clinical Article

10 Differentiating early-onset chronic depression from episodic depression in terms of cognitive-behavioral and emotional avoidance Journal of Affective Disorders, January 30, 2015    Clinical Article

11 Long-term efficacy and tolerability of quetiapine in patients with schizophrenia who switched from other antipsychotics because of inadequate therapeutic response— A prospective open-label study Full Text Annals of General Psychiatry, January 30, 2015    Clinical Article

12 Group therapy for adolescents with attention-deficit/hyperactivity disorder: A randomized controlled trial Journal of the American Academy of Child & Adolescent Psychiatry, January 30, 2015    Clinical Article

13 A systematic review and meta-analysis of randomized controlled trials of adjunctive ketamine in electroconvulsive therapy: Efficacy and tolerability Journal of Psychiatric Research, January 30, 2015    Evidence Based Medicine   Clinical Article

14 Anxiety and its relationship to quality of life independent of depression in patients with obstructive sleep apnea Journal of Psychosomatic Research, January 30, 2015    Clinical Article

15 Increased risk of progression to dialysis or death in CKD patients with depressive symptoms: A prospective 3-year follow-up cohort study Journal of Psychosomatic Research, January 30, 2015    Clinical Article

16 Multiparametric magnetic resonance imaging enhances detection of significant tumor in patients on active surveillance for prostate cancer Urology, January 30, 2015    Clinical Article

17 A phase II randomized clinical trial of a nutritional formulation for cognition and mood in Alzheimer's disease Journal of Alzheimer’s Disease, January 30, 2015    Clinical Article

18 Ameliorating treatment-refractory depression with intranasal ketamine: Potential NMDA receptor actions in the pain circuitry representing mental anguish CNS Spectrums, January 30, 2015    Review Article

19 Impact of a behavioural sleep intervention on symptoms and sleep in children with attention deficit hyperactivity disorder, and parental mental health: Randomised controlled trial BMJ, January 30, 2015    Clinical Article

20 The use of Alcohol Use Disorders Identification Test (AUDIT) in detecting alcohol use disorder and risk drinking in the general population: Validation of AUDIT using Schedules for Clinical Assessment in Neuropsychiatry Alcoholism: Clinical and Experimental Research, January 30, 2015    Clinical Article

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Highlights in Family Medicine

Belimumab safe and effective in childhood-onset SLE

As reported in Arthritis and Rheumatology, belimumab (a human monoclonal antibody targeting soluble B-lymphocyte stimulator) is effective and well-tolerated in children with SLE (n=7). The mean follow-up was 9.3 months. The SLEDAI decreased from 6.4 to 4 and 57% of recipients were able to taper steroids. Clinical response was evident by 3 months.

Combination tiotropium + formoterol superior to tiotropium alone in COPD patients

As reported in Pulmonary Pharmacology & Therapeutics, combination tiotropium (18 mcg) + formoterol (12 mcg) was superior to tiotropium alone in COPD (n=44) patients inadequately controlled with bronchodilator monotherapy. Combination therapy resulted in an increased bronchodilator response (FEV1 and FVC) and a maximum change in FEV1 and FVC over 24 h.

Triple therapy superior to dual therapy in HCV

As reported in Mayo Clinic Proceedings, treatment of hepatitis C virus-infected patients with triple therapy (pegylated-interferon, ribavirin, and teleprevir) is more effective than dual therapy (pegylated-interferon and ribavirin). Specifically, a sustained virologic response was achieved in 51% of treatment-naïve patients, 67% of patients with a prior non-response and 56% of patients with a prior relapse of patients treated with triple therapy compared to 37%, 11%, and 27% of patients treated with dual therapy, respectively.

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