Effect of Therapeutic Hypothermia on Oxidative Stress and Outcome in Term Neonates with Perinatal Asphyxia: A Randomized Controlled Trial
Journal of Tropical Pediatrics, 08/21/2012
Joy R et al. – Therapeutic hypothermia (TH) reduces oxidative stress and improves neurological outcome in perinatal asphyxia.Methods
- Babies who satisfied inclusion criteria were randomized to TH, with cooling gel packs to a target temperature of 33–34°C for 72 h or normothermia.
- Blood sample was collected before and after TH for oxidative stress assessment: total antioxidant status (TAS) and malondialdehyde (MDA).
- Of 116 babies randomized, there was no statistically significant difference in the baseline TAS and MDA.
- After 72 h of TH, TAS was significantly higher (p = <0.001) (761.69 ± 114.01 vs. 684.16 ± 88.86) and MDA was significantly lower (p = <0.001) in TH group (1.73 ± 0.66 vs. 5.2 ± 1.06).
- Risk of developing deficit was lower (p < 0.001) in TH group with relative risk of 0.49 and 95 % confidence interval: 0.29–0.68.