Chemerin Is Present In Human Cord Blood and Is Positively Correlated with Birth Weight.
American Journal of Obstetrics and Gynecology, 08/17/2012
Clinical Article
Mazaki–Tovi S et al. – The aims of this study were to determine the presence of chemerin in cord blood and its association with birth weight. Chemerin, a novel adipokine, has been implicated in adipogenesis, inflammation and metabolism. It was seen that cord blood chemerin is present in cord blood and its concentrations are positively correlated with birth weight. These novel findings support a role of adipokines in fetal growth.
Methods- This cross–sectional study included: 1) twins with (n=24) or without (n=28) birth weight discordancy; and 2) singletons sub–classified into: i) SGA (n=18); ii) AGA (n=33); and iii) LGA (n=8).
- Cord blood chemerin was determined.
- Parametric and Non–parametric statistics were used for analysis.
- Within the discordant twins group, the median chemerin concentration was significantly lower in the SGA than in their co–twins;
- within singletons, median chemerin concentration was significantly higher in LGA than AGA newborns
- regression model revealed that chemerin was independently associated with birth weight.
