CCR7 ligands up-regulate IL-23 through PI3-kinase and NF-κB pathway in dendritic cells
Journal of Leukocyte Biology, 08/10/2012
Kuwabara T et al. – The authors concluded that PI3K and NF–κB signaling pathways play a critical role in CCR7–mediated IL–23 production in murine DCs. As IL–23 contributes to Th17 cell generation, and Th17 cells are pathogenic in autoimmune diseases, precise elucidation of these mechanisms would contribute to the development of strategies to control autoimmune diseases.
