Effect of levosimendan on estimated glomerular filtration rate in hospitalized patients with decompensated heart failure and renal dysfunction
Cardiovascular Therapeutics, 07/31/2012
Hou ZQ et al. – A 24–hour infusion with levosimendan transiently improved the renal dysfunction compared with placebo in patients with decompensated heart failure (DHF), and its beneficial effects persisted for at least 14 days after the initiation of treatment.Methods
- A prospective, randomized, placebo–controlled and double–blind study was performed to investigate the effect of levosimendan on estimated glomerular filtration rate (eGFR) in DHF patients with renal dysfunction during a 30–day period.
- 66 patients with left ventricular ejection fraction (LVEF) ≤ 40% and eGFR 15–89 ml/min/1.73m2 were randomized in a 1:1 ratio to receive a 24–hour infusion with levosimendan or placebo.
- The B–type natriuretic peptide (BNP) and eGFR were determined at baseline and day 1, 3, 7, 14, 30 after the start of treatment.
- The eGFR levels were obviously enhanced following levosimendan, peaked at 3 days, sustained for at least 14 days and returned to baseline by day 30 after starting infusion.
- In contrast, placebo did not induce any significant changes in eGFR levels during the follow–up.
- In addition, levosimendan resulted in a distinct decrease in BNP levels in comparison with placebo, and the beneficial effect returned to baseline by day 14 and remained so at day 30 post–infusion.