Time-dependent O2 consumption patterns determined optimal time ranges for selecting viable human embryos
Fertility and Sterility, 08/03/2012
Tejera A et al. – This retrospective cohort study evaluates the correlations between metabolic activity and implantation potential of transferred embryos in a study based on oxygen (O2) consumption (OC) measurements, because O2 uptake is directly related to the capacity of an embryo to produce energy via adenosine triphosphate.OC was found to decrease during embryonic development. OC patterns from 52 hours onward showed the strongest correlation with implantation success. Regarding embryo destination, the same patterns were observed. OC from individual embryos revealed significant differences, mainly close to the time of transfer, when OC pattern was associated with successful implantation. Therefore, measuring the OC pattern of human embryos culture up to 72 hours could be used to select the embryo with best developmental potential.