Effects of Cotrimoxazole Prophylactic Treatment on Adverse Health Outcomes Among HIV-exposed, Uninfected Infants
The Pediatric Infectious Disease Journal, 07/31/2012
Dow A et al. – Cotrimoxazole prophylactic treatment (CPT) offered temporary protection against malaria among HIV–exposed, uninfected infants. However, CPT offered no protection against anemia, low weight for age or the collapsed outcome of severe illness or death.Methods
- For the analysis, they assigned a status of CPT-exposed to infants who were participating in the study after the CPT program started.
- They estimated unadjusted and adjusted hazard ratios for the effect of CPT status on time to incident malaria, severe illness or death, anemia, and weight-for-age Z score <2.0.
- Participation in the study was limited to focus exclusively on HIV-exposed, uninfected infants.
- The hazard ratio for the effect of CPT on incident malaria was 0.35 (95% confidence interval: 0.21, 0.57) during the first 10 weeks of CPT exposure and 0.93 (95% confidence interval: 0.67, 1.29) for the remaining 20 weeks.
- CPT was not associated with the other outcomes examined.