Concepts in Psoriasis: Psoriasis and the Extracellular Matrix
British Journal of Dermatology, 07/16/2012
McFadden J et al. – In normal skin α5β1 expression is minimal or absent in resting epithelial cells, where basal cells are anchored to the laminin component of the basement membrane (via integrins α6β4 and α3β1). However, when the laminin layer is disrupted, due to wounding for instance, α5β1 is then strongly expressed by basal cells as a means for anchoring.