Increased fasting serum glucose concentration is associated with adverse knee structural changes in adults with no knee symptoms and diabetes
Davies–Tuck M. L et al. – This longitudinal cohort study is performed to examine the relationship between serum glucose concentration and knee structure in adults with no knee symptoms or diabetes. There is evidence to suggest that elevated glucose concentration and clinical diabetes are associated with osteoarthritis (OA). However, the association may be confounded by knee symptoms, concomitant treatment for OA or diabetes.It was seen that increased fasting serum glucose concentration in a non–diabetic population was associated with adverse structural changes at the knee in women but not in men, suggesting that there may be susceptibility to knee structural change even below the arbitrary “diabetic range” of serum glucose levels. The sex differences warrant further investigation as this may be one mechanism underlying the sex difference in knee OA.