Risk factor reduction in progression of angiographic coronary artery disease
Archives of Medical Science, 07/11/2012
Lai HM et al. – The data suggest that in addition to using appropriate medical therapy, control of blood pressure and serum low–density lipoprotein cholesterol (LDL–C) level may reduce progression of coronary artery disease (CAD).Methods
- Chart reviews were performed in patients in an outpatient cardiology practice having ≥ 2 coronary angiographies ≥ 1 year apart.
- Progressive CAD was defined as 1) new non–obstructive or obstructive CAD in a previously disease–free vessel; or 2) new obstruction in a previously non–obstructive vessel.
- Coronary risk factors, comorbidities, cardiovascular events, medication use, serum low–density lipoprotein cholesterol (LDL–C), and blood pressure were used for analysis.
- The study included 183 patients, mean age 71 years. Mean follow–up duration was 11 years.
- Mean follow–up between coronary angiographies was 58 months.
- Of 183 patients, 108 (59%) had progressive CAD, and 75 (41%) had nonprogressive CAD.
- The use of statins, β–blockers, angiotensin–converting enzyme inhibitors or angiotensin receptor blockers, and aspirin was not significantly different in patient with progressive CAD or nonprogressive CAD
- Mean arterial pressure was higher in patients with progressive CAD than in patients with nonprogressive CAD (97 ±13 mm Hg vs. 92 ±12 mm Hg) (p < 0.05).
- Serum LDL–C was insignificantly higher in patients with progressive CAD (94 ±40 mg/dl) than in patients with nonprogressive CAD (81 ±34 mg/dl) (p = 0.09).