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The Efficacy of Second-Line Anti-Helicobacter pylori Therapy Using an Extended 14-Day Levofloxacin/Amoxicillin/Proton-Pump Inhibitor Treatment - A Pilot Study
Helicobacter,  Clinical Article

Chuah SK et al. – A 14–day levofloxacin/amoxicillin/esomeprazole triple therapy approach provides a >90% per–protocol report card with the caveat that this approach is markedly less effective in the presence of fluoroquinolone resistance. Levofloxacin–resistant strains are increasing in Taiwan.

Methods
  • One–hundred and one patients who failed H. pylori eradication using the standard triple therapy for 7 days were randomly assigned to either a levofloxacin/amoxicillin/esomeprazole group (levofloxacin 500 mg once daily, amoxicillin 1 g twice daily, and esomeprazole 40 mg twice daily for 14 days) or a esomeprazole/metronidazole/bismuth salt/tetracycline group (esomeprazole 40 mg twice daily, metronidazole 250 mg four times daily, tripotassium dicitrate bismuthate 300 mg four times daily, and tetracycline 500 mg four times daily for 14 days).
  • Follow–up to assess treatment response consisted of either endoscopy or a urea breath test, which were carried out 8 weeks later.

Results
  • Eradication rates attained by levofloxacin/amoxicillin/esomeprazole and esomeprazole/metronidazole/bismuth salt/tetracycline treatments in the per–protocol analysis were 44/47 (93.6%; 95% CI=86–99.8) and 43/47 (91.8%; 95% CI=83.2–98.5).
  • In the intention–to–treat analysis, these were 43/47 (86.3%; 95% CI=76.5–96.1) in the LAE group (four lost to follow–up) and 43/50 (86%; 95% CI=76–96) in the EMBT groups.
  • The observed adverse events were 25.5% and 38.5% among the two groups.
  • There was 100% drug compliance among the levofloxacin/amoxicillin/esomeprazole group.
  • Levofloxacin–resistant strains occurred at a frequency of 32.3%. H. pylori eradication rates for the levofloxacin–susceptible strains and levofloxacin–resistant strains were 92% (11/12) and 33% (1/3) in the per–protocol analysis.

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