Cerebral tissue hemoglobin saturation in children with sickle cell disease
Pediatric Blood & Cancer, 06/21/2012
Quinn CT et al. – Cerebral desaturation, a physiologic marker of at–risk brain, is common in sickle cell disease (SCD), more severe in HbSS/Sbeta0 patients, and associated with peripheral desaturation, more severe anemia, and increasing age. Cerebral oximetry has the potential to improve the identification of children with SCD at highest risk of neurologic injury and possibly serve as a physiologic guide for neuroprotective therapy.