Mipomersen: evidence-based review of its potential in the treatment of homozygous and severe heterozygous familial hypercholesterolemia
Core Evidence, 06/07/2012
Parhofer KG – The most common side effects are injection site reactions (70%–100%), flu–like symptoms (29%–46%), and elevated transaminases associated with an increased liver fat content (6%–15%). Mipomersen may be an interesting addon drug in patients with heterozygous or homozygous FH not reaching treatment goals, either because baseline values are very high or because high–dose statins are not tolerated.Methods
- Familial hypercholesterolemia (FH) is an autosomal–dominant inherited disease with a prevalence of one in 500 (heterozygous) to one in 1,000,000 (homozygous).
- Mutations of the low–density lipoprotein (LDL) receptor gene, the apolipoprotein B100 gene, or the PCSK9 gene may be responsible for the disease.
- The resulting LDL hypercholesterolemia results in premature atherosclerosis as early as childhood (homozygous FH) or in adulthood (heterozygous FH).
- Current treatment modalities include lifestyle modification, combination drug therapy (statin–based), and apheresis.
- Mipomersen is an antisense oligonucleotide which inhibits apolipoprotein B production independent of LDL receptor function and thus works in homozygous FH, heterozygous FH, and other forms of hypercholesterolemia.
- Mipomersen is given 200 mg/week subcutaneously.
- Phase III studies indicate that the LDL cholesterol concentration can be reduced by 25%–47%, lipoprotein(a) levels by 20%–40%, and triglyceride concentrations by approximately 10%.
- In general, mipomersen has no effect on high–density lipoprotein cholesterol concentrations.
- Although there is considerable interindividual variability, the observed lipid effects are largely independent of age, gender, concomitant statin therapy, and underlying dyslipoproteinemia.