Aspirin-Intolerant Asthma (AIA) Assessment Using the Urinary Biomarkers, Leukotriene E4 (LTE4) and Prostaglandin D2 (PGD2) Metabolites Full Text
Higashi N et al. – This finding suggests the possibility that increased mast cell activation is involved in the pathophysiology of aspirin–intolerant asthma (AIA) even in a clinically stable condition. In addition, lower urinary concentrations of primary prostaglandin E2 and 15–epimer of lipoxin A4 at baseline in the AIA patients suggest that the impaired anti–inflammatory elements may also contribute to the severe clinical outcome of AIA. During the AIA reaction, the urinary concentrations of LTE4 and PGD2 metabolites, including tetranor–PGDM significantly and correlatively increase. It is considered that mast cell activation probably is a pathophysiologic hallmark of AIA.