Additive renoprotective effects of aliskiren on angiotensin receptor blocker and calcium channel blocker treatments for type 2 diabetic patients with albuminuria
Abe M et al. – This results suggest that the addition of aliskiren to the maximal recommended dose of angiotensin II receptor blocker (ARB) and usual dose of amlodipine is more effective in reducing albuminuria and oxidant stress in hypertensive diabetic patients with chronic kidney disease (CKD) than increasing the dose of amlodipine.Methods
- This open–label, randomized, parallel–controlled study.
- Investigated the effects of the direct renin inhibitor aliskiren on 64 hypertensive type 2 diabetic patients with chronic kidney disease (CKD) and stable glycemic control who were already being treated with fixed doses of antihypertensive agents over a 24–week period.
- These agents were 80mg of the angiotensin II receptor blocker (ARB) telmisartan and 5mg of the calcium channel blocker (CCB) amlodipine.
- Patients were randomly assigned to two groups: the aliskiren group, receiving 150mg per day aliskiren, which was increased to 300mg per day (n=32), and the CCB group, which received an increased dose (7.5mg per day) of amlodipine that was increased to 10mg per day (n=32).
- Urinary albumin excretion and urinary levels of 8–hydroxy–2’–deoxyguanosine (8–OHdG) and liver–type fatty acid–binding protein (L–FABP) were investigated in each group.
- Mean systolic and diastolic blood pressure decreased significantly in both groups, but there was no significant difference between the two groups at the end of the study.
- Serum creatinine levels and estimated glomerular filtration rate did not differ significantly between the two groups, but percent changes of urinary albumin/creatinine ratios, 8–OHdG and L–FABP levels decreased significantly in the aliskiren group compared with the CCB group.
- Plasma aldosterone levels were significantly decreased in the aliskiren group, which correlated significantly with those of urinary 8–OHdG and L–FABP.