Skin Ceramide Alterations In First-Episode Schizophrenia Indicate Abnormal Sphingolipid Metabolism Full Text
Schizophrenia Bulletin, 05/16/2012
Smesny S et al. – The authors found highly significant increase of ceramide AH and NH/AS classes in patients and decrease of EOS and NP ceramide classes. This is the first demonstration of specific peripheral sphingolipid alterations in schizophrenia. The results support recent models of systemic lipid pathology and in particular of specific sphingolipids, which are crucial in neuronal membrane integrity.