The transcription factor AP-1 is involved in ICOS gene expression downstream of TCR/CD28 signaling and cytokine receptor signaling

European Journal of Immunology, 05/17/2012

The results indicate AP–1 transcription factors are involved in ICOS gene expression downstream of both TCR/CD28 signaling and cytokine receptor signaling, and suggest AP–1 activation via cytokine receptor signaling may be one of the mechanisms maintaining high level ICOS expression in chronic inflammatory immune responses.

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