Zoledronic acid suppresses mineralization through direct cytotoxicity and osteoblast differentiation inhibition
Journal of Oral Pathology & Medicine, 05/24/2012
Patntirapong S et al. – With this in vitro study, Zoledronic acid (ZA) mediated defective bone mineralization by directly disrupting osteoblast/osteoprogenitor cellular activities at several levels, that is, cell proliferation, osteoblast differentiation, and osteoblast function of both pre–osteoblastic cells and mesenchymal stem cell (MSC).



