Treatment-completion rates with olanzapine long-acting injection versus risperidone long-acting injection in a 12-month, open-label treatment of schizophrenia: indirect, exploratory comparisons Full Text
International Journal of General Medicine,  Clinical Article

Ascher–Svanum H et al. – Using treatment–completion rates as a proxy measure of medication effectiveness, olanzapine long–acting injection did not differ significantly from risperidone long–acting injection when including all eligible studies. However, the findings of this exploratory analysis should be interpreted with caution, considering the methodological limitations of these indirect, cross–study comparisons.

Methods
  • Indirect, cross–study comparisons between olanzapine long–acting injection and risperidone long–acting injection used 12–month treatment–completion rates, because discontinuation of an antipsychotic for any cause is a recognized proxy measure of the medication's effectiveness in treating schizophrenia.
  • Following a systematic review of the literature, two indirect comparisons were conducted using open–label, single–cohort studies in which subjects were stabilized on an antipsychotic medication before depot initiation.
  • The first analysis compared olanzapine long–acting injection (one study) with pooled data from nine identified risperidone long–acting injection studies.
  • The second analysis was a “sensitivity analysis,” using only the most similar studies, one for olanzapine long–acting injection and one for risperidone long–acting injection, which shared near–identical study designs and involved study cohorts with near–identical patient characteristics.
  • Pearson Chi–square tests assessed group differences on treatment–completion rates.

Results
  • Comparison of olanzapine long–acting injection data (931 patients) with the pooled data from the nine risperidone long–acting injection studies (3950 patients) provided almost identical 12–month treatment–completion rates (72.7% versus 72.4%; P = 0.87).
  • When the two most similar studies were compared, the 12–month completion rate for olanzapine long–acting injection was significantly higher than for risperidone long–acting injection (81.3% versus 47.0%; P < 0.001).
  • However, any conclusions drawn from this comparison may be limited by differences in the studies' geographic catchment areas.

Please login or register to follow this author.
Are you sure you want to Unfollow this Author?
► Click here to access Full Text, PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

Your Unread Messages in Family Medicine

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Family Medicine Articles

1 A comparison of the effects of hatha yoga and resistance exercise on mental health and well-being in sedentary adults: A pilot study Complementary Therapies in Medicine, June 11, 2014    Clinical Article

2 Short-term effects of a manual therapy protocol on pain, physical function, quality of sleep, depressive symptoms, and pressure sensitivity in women and men with fibromyalgia syndrome: A randomized controlled trial The Clinical Journal of Pain, June 9, 2014    Clinical Article

3 Depression treatment by withdrawal of short-term low-dose antipsychotic, a proof-of-concept randomized double-blind study Journal of Affective Disorders, June 16, 2014    Clinical Article

4 Benefits and harms in clinical trials of duloxetine for treatment of major depressive disorder: comparison of clinical study reports, trial registries, and publications BMJ, June 12, 2014    Clinical Article

5 A comparison of the effects of hatha yoga and resistance exercise on mental health and well-being in sedentary adults: A pilot study Complementary Therapies in Medicine, June 19, 2014    Clinical Article

6 The effect of green tea on blood pressure and lipid profile: A systematic review and meta-analysis of randomized clinical trials Nutrition, Metabolism & Cardiovascular Diseases, March 27, 2014    Evidence Based Medicine    Review Article

7 Risk of myocardial infarction and stroke in bipolar disorder: A systematic review and exploratory meta-analysis Acta Psychiatrica Scandinavica, May 30, 2014    Evidence Based Medicine    Review Article

8 Impact of mindfulness-based cognitive therapy on health care utilization: a population-based controlled comparison Journal of Psychosomatic Research, June 26, 2014    Clinical Article

9 Prognostic impact of the serum heart-type fatty acid-binding protein (H-FABP) levels in patients admitted to the non-surgical intensive care unit Clinical Research in Cardiology, May 23, 2014    Clinical Article

10 Effect of dietary restriction on peripheral monoamines and anxiety symptoms in obese subjects with metabolic syndrome Psychoneuroendocrinology, June 24, 2014    Clinical Article

11 Efficacy and safety of olanzapine/fluoxetine combination vs fluoxetine monotherapy following successful combination therapy of treatment-resistant major depressive disorder Neuropsychopharmacology, June 2, 2014    Clinical Article

12 Duloxetine-bupropion combination for treatment-resistant atypical depression: A double-blind, randomized, placebo-controlled trial European Neuropsychopharmacology, May 22, 2014    Clinical Article

13 The association of internet addiction symptoms with anxiety, depression and self-esteem among adolescents with attention-deficit/hyperactivity disorder Comprehensive Psychiatry, June 17, 2014    Clinical Article

14 The impact of anxious symptoms in the remission of depressive symptoms in a clinical trial for depression: Follow-up of six months Journal of Affective Disorders, June 10, 2014    Clinical Article

15 Pharmacological and non-pharmacological interventions to improve cognitive dysfunction and functional ability in clinical depression – A systematic review Psychiatry Research, June 18, 2014    Evidence Based Medicine    Review Article

16 Efficacy and tolerability of antidepressants for sub-threshold depression and for mild major depressive disorder Journal of Affective Disorders, June 16, 2014    Evidence Based Medicine    Review Article

17 Changes in circulating leptin levels during acute stress and associations with craving in abstinent smokers: A preliminary investigation Psychoneuroendocrinology, June 20, 2014    Clinical Article

18 Individual mindfulness-based cognitive therapy (MBCT) and cognitive behavior therapy (CBT) for treating depressive symptoms in patients with diabetes: Results of a randomized controlled trial Diabetes Care, June 6, 2014    Clinical Article

19 Depression with atypical features and increase in obesity, body mass index, waist circumference, and fat mass : a prospective, population-based study JAMA Psychiatry, June 13, 2014    Clinical Article

20 Self-relevant disgust and self-harm urges in patients with borderline personality disorder and depression: A pilot study with a newly designed psychological challenge PLOS ONE, June 27, 2014    Clinical Article

Indexed Journals in Family Medicine: American Family Physician, Archives of Family Med, Annals of Family Medmore

Register now to view all the MDLinx contents (FREE)!

  • Stay current on the latest literature, research and clinical news
  • Get special communications and offers from MDLinx and our sponsors
  • Receive invitations to paid market research
View Samples and Register

Connect with us, stay current.

Receive the latest mecial news
updates for free via email

Sign up!

Subscribe to our free RSS feeds:

Get the latest news in your specialty automatically added to your newsreader or your personal My Yahoo!, Google, My MSN or My AOL page. Learn More

Close