Effect of beta blocker therapy on survival of patients with heart failure and preserved systolic function following hospitalization with acute decompensated heart failure
European Journal of Internal Medicine , 05/09/2012
Nevzorov R et al. – Therapy with beta blockers may have protective effect on survival of patients with heart failure with preserved systolic functionMethods
- The authors performed a retrospective cohort analysis of 345 consecutive patients with heart failure with preserved systolic function older than 18years hospitalized due to decompensated heart failure.
- Two groups of patients were compared: those who received beta blockers within 3months before admission (BB) and those who did not (NBB).
- The primary outcome was two year all cause mortality (maximal follow–up available in all subjects).
- To adjust for a potential misbalance between BB and NBB groups in baseline characteristics, a propensity score for beta blocker therapy was incorporated into the survival model.
- 154 patients (44.6%) received beta blockers prior to admission.
- Overall two year mortality rate in the BB group was 50% vs. 62.8% in the NBB group, log–rank test p=0.016.
- Beta blockers showed protective effect on two–year survival after adjustment for comorbidities and propensity score (hazard ratio [HR], 0.69; 95% CI 0.47–0.99).