Rassmussen M-L H et al. – While causality could not be established in the present study, an intriguing positive long-term association between antibiotic use and CLL/SLL risk was observed.
The aim of this study was, in a cohort design, based on the unique nationwide Danish registers, to investigate the association between use of antibiotics and the risk of NHL subtypes.
Based on the Civil Registration System, we established a cohort of the entire adult (?15y) Danish population. Information on use of antibiotics came from the Danish Drug Prescription Registry and lymphoma diagnosis from the Danish Cancer Registry.
In total, 13,602 patients were diagnosed with one of the NHL subtypes during 51.6 million person-years of follow-up (1995-2008).
We observed positive associations between use of antibiotics and plasma cell myeloma (PCM) (RR=1.11, 95% confidence intervals (CI)=1.00 to 1.24), chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) (RR=1.32, 95% CI=1.20 to 1.45), mantle cell lymphoma (MCL) (RR=1.40, 95% CI=1.04-1.88) and anaplastic large T-cell lymphoma (ALCL) (RR=1.83, 95% CI=1.00 to 3.36).
Among these, the increased risk of CLL/SLL, MCL and ALCL, respectively, did not vary by years since use, and only the risk of CLL/SLL risk differed by number of prescriptions.
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