Positron Emission Tomography Shows Elevated Cannabinoid CB1 Receptor Binding in Men with Alcohol Dependence

Alcoholism: Clinical and Experimental Research, 05/04/2012

The findings agree with preclinical evidence and provide the first, albeit still preliminary in vivo evidence suggesting a role for brain cannabinoid type 1 (CB1) receptors in alcohol dependence (AD). The current study design does not answer the important question of whether elevated CB1 receptors are a preexisting vulnerability factor for AD or whether elevations develop as a consequence of AD.

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