Bias in effect size of Systemic Lupus Erythematosus susceptibility loci across Europe: a case control study Full Text
Arthritis Research & Therapy, 05/02/2012
Alonso–Perez E et al. – The findings showed a bias to larger effect sizes of Systemic Lupus Erythematosus (SLE) loci in the Southern Europeans relative to the Central Europeans together with clines of SLE risk allele frequencies. These results indicate the need to study risk allele clines and the implications of the polygenic model of inheritance in SLE.