mdlinx mdlinx
Latest (181) Full Text Articles (5432) Focus on COPD Article Summary

Controlled release formulation of oxycodone in patients with moderate to severe chronic osteoarthritis: a critical review of the literature Full Text
Journal of Pain Research,

Taylor R et al. – Analysis of the studies revealed that oxycodone controlled release (CR) is reasonably efficacious, safe, and tolerable when used to manage moderate to severe chronic osteoarthritis (OA) pain, with similar side effects to that of other opioids.

  • Osteoarthritis (OA) is a physically and emotionally debilitating disease that predominantly affects the aging adult population.
  • Current pharmacologic treatment options primarily consist of nonsteroidal anti–inflammatory drugs and/or acetaminophen, but associated side effects, analgesic limitations, especially in the elderly, and the need for around–the–clock analgesia have led physicians to search for alternative analgesics.
  • Opioids have shown effectiveness at mitigating both chronic cancer and noncancer pain, and their ability to be placed into controlled release (CR) formulations suggests that they may prove efficacious for OA patients.
  • One formulation, oxycodone CR, has shown effectiveness in cancer pain patients and in some trials of noncancer low back pain.
  • In this review, the objective was to synthesize the reported findings by researchers in this field and present an up–to–date look at the efficacy, safety, and tolerability of oxycodone CR in OA patients.
  • Public literature databases were searched using specific keywords (eg, oxycodone CR) for studies assessing the efficacy and safety profile of oxycodone CR and its use in patients with OA.
  • A total of eleven articles that matched the criteria were identified, which included three placebo–controlled trials, six comparative trials, one pharmacokinetic study in the elderly, and one long–term safety trial.

Please login or register to follow this author.
Are you sure you want to Unfollow this Author?
► Click here to access Full Text, PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

Your Unread Messages in Family Medicine

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Family Medicine Articles

Last month's top read Top Articles of 2013

1 Coffee consumption and prostate cancer risk: An updated meta-analysis Cancer Causes and Control, March 3, 2014    Evidence Based Medicine    Clinical Article

2 Coffee intake and gastric cancer risk Cancer Epidemiology, Biomarkers & Prevention, March 10, 2014    Clinical Article

3 Tea consumption and the risk of five major cancers: A dose-response meta-analysis of prospective studies Full Text BMC Cancer, March 18, 2014    Free full text    Evidence Based Medicine    Review Article

4 Coffee intake and gastric cancer risk Cancer Epidemiology, Biomarkers & Prevention, March 19, 2014    Clinical Article

5 Is ginger effective for the treatment of irritable bowel syndrome? A double blind randomized controlled pilot trial Complementary Therapies in Medicine, March 4, 2014    Clinical Article

6 Associations between serum 25-hydroxyvitamin D concentrations and multiple health conditions, physical performance measures, disability, and all-cause mortality: The Concord Health and Ageing in Men Project Journal of the American Geriatrics Society, March 13, 2014    Clinical Article

7 Egg consumption and cardiovascular disease among diabetic individuals: A systematic review of the literature Full Text Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, March 28, 2014    Free full text    Review Article

8 Effects of pomegranate juice consumption on inflammatory markers in patients with type 2 diabetes: A randomized, placebo-controlled trial Journal of Research in Medical Sciences, March 20, 2014    Clinical Article

9 Effects of yoga on cardiovascular disease risk factors: A systematic review and meta-analysis International Journal of Cardiology, March 17, 2014    Evidence Based Medicine    Review Article    Clinical Article

10 Effect of omega-3 fatty acid supplementation on cancer incidence, non-vascular death, and total mortality: a meta-analysis of randomized controlled trials Full Text BMC Public Health, March 5, 2014    Free full text    Evidence Based Medicine    Clinical Article

11 The effect of green tea on blood pressure and lipid profile: A systematic review and meta-analysis of randomized clinical trials Nutrition, Metabolism & Cardiovascular Diseases, March 27, 2014    Evidence Based Medicine    Review Article

12 The effect of three weeks green tea extract consumption on blood pressure, heart rate responses to a single bout resistance exercise in hypertensive women High Blood Pressure & Cardiovascular Prevention, March 14, 2014    Clinical Article

13 Meat consumption and the risk of hepatocellular carcinoma Alimentary Pharmacology and Therapeutics, March 6, 2014    Review Article

14 Tea consumption and leukemia risk: A meta-analysis Tumor Biology, February 12, 2014    Evidence Based Medicine    Clinical Article

15 Is breakfast skipping associated with physical activity among US adolescents? A cross-sectional study of adolescents aged 12–19 years, National Health and Nutrition Examination Survey (NHANES) Public Health Nutrition, March 12, 2014    Clinical Article

16 Dietary carrot consumption and the risk of prostate cancer European Journal of Nutrition, February 17, 2014    Clinical Article

17 The association between caffeine and cognitive decline: Examining alternative causal hypotheses International Psychogeriatrics, March 18, 2014    Review Article

18 Estimation of fish intake in Asian and white female adolescents, and association with 2-year changes in body fatness and body fat distribution: The Female Adolescent Maturation Study Journal of the Academy of Nutrition and Dietetics, March 24, 2014    Clinical Article

19 The low-carbohydrate diet and cardiovascular risk factors: Evidence from epidemiologic studies Nutrition, Metabolism & Cardiovascular Diseases, March 12, 2014    Evidence Based Medicine    Review Article

20 A green and black tea extract benefits urological health in men with lower urinary tract symptoms Therapeutic Advances in Urology, March 26, 2014    Clinical Article

Indexed Journals in Family Medicine: American Family Physician, Archives of Family Med, Annals of Family Medmore

Other Topics in Family Medicine

Register now to view all the MDLinx contents (FREE)!

  • Stay current on the latest literature, research and clinical news
  • Get special communications and offers from MDLinx and our sponsors
  • Receive invitations to paid market research
View Samples and Register

Stay current - Media Tool

Newsletter
RSS
Follow
Like

Receive the latest mecial news
updates for free via email

Sign up!

Subscribe to our free RSS feeds:

Get the latest news in your specialty automatically added to your newsreader or your personal My Yahoo!, Google, My MSN or My AOL page. Learn More

Close