Effective connectivity of AKT1-mediated dopaminergic working memory networks and pharmacogenetics of anti-dopaminergic treatment Full Text
Brain,  Clinical Article

Tan HY et al. – The authors suggest that genetic modulation of DRD2–AKT1–related prefrontal–subcortical circuits could at least in part influence cognitive dysfunction in psychosis and its treatment.

Methods
  • The authors examined predictions from basic models of dopaminergic signalling in cortical and cortical–subcortical circuitries implicated in dissociable working memory maintenance and manipulation processes.
  • They also examined pharmacogenetic effects on cognition in the context of anti–dopaminergic drug therapy.
  • Using dynamic causal models of functional magnetic resonance imaging in normal subjects (n=46), they identified differentiated effects of functional polymorphisms in COMT, DRD2 and AKT1 genes on prefrontal–parietal and prefrontal–striatal circuits engaged during maintenance and manipulation, respectively.

Results
  • Cortical synaptic dopamine monitored by the COMT Val158Met polymorphism influenced prefrontal control of both parietal processing in working memory maintenance and striatal processing in working memory manipulation.
  • DRD2 and AKT1 polymorphisms implicated in DRD2 signalling influenced only the prefrontal–striatal network associated with manipulation.
  • In the context of anti–psychotic drugs, the DRD2 and AKT1 polymorphisms altered dose–response effects of anti–psychotic drugs on cognition in schizophrenia (n=111).

Please login or register to follow this author.
► Click here to access Full Text, PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

Your Unread Messages in Family Medicine

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Family Medicine Articles

1 Influence of metformin use on PSA values, free-to-total PSA, prostate cancer incidence and grade and overall survival in a prospective screening trial (ERSPC Aarau) World Journal of Urology, November 3, 2014    Clinical Article

2 Impact of the 2012 United States preventive services task force statement on prostate-specific antigen screening: Analysis of urologic and primary care practices Urology, November 17, 2014    Clinical Article

3 Dairy products, calcium, and prostate cancer risk: A systematic review and meta-analysis of cohort studies American Journal of Clinical Nutrition, November 26, 2014    Clinical Article

4 Radical prostatectomy in high-risk and locally advanced prostate cancer: Mayo Clinic perspective Urologic Oncology: Seminars and Original Investigations, November 10, 2014    Clinical Article

5 Role of ultrasensitive prostate-specific antigen in the follow-up of prostate cancer after radical prostatectomy Urologic Oncology: Seminars and Original Investigations, November 24, 2014    Clinical Article

6 Folate, vitamin B-6, and vitamin B-12 intake and mild cognitive impairment and probable dementia in the Women’s Health Initiative Memory Study Journal of the Academy of Nutrition and Dietetics, November 12, 2014    Clinical Article

7 Association of fat density with subclinical atherosclerosis Full Text Journal of the American Heart Association, September 19, 2014    Free full text

8 Acupuncture and immune function in chronic prostatitis/chronic pelvic pain syndrome: a randomized, controlled study Complementary Therapies in Medicine, October 31, 2014    Clinical Article

9 Rapid and durable protection against Ebola virus with new vaccine regimens Full Text National Institute of Allergy and Infectious Disease - News, September 9, 2014    Free full text

10 Sexual function in men with lower urinary tract symptoms and prostatic enlargement secondary to benign prostatic hyperplasia: Results of a 6-month, randomized, double-blind, placebo-controlled study of tadalafil coadministered with finasteride The Journal of Sexual Medicine, November 7, 2014    Clinical Article

11 An European multicenter randomized noninferiority trial comparing 180-W greenlight-XPS laser vaporization and transurethral resection of the prostate for the treatment of benign prostatic obstruction: 12-months results of the goliath-study The Journal of Urology, November 4, 2014    Clinical Article

12 State-of-the-art treatment of hypertension: Established and new drugs Full Text European Heart Journal, November 14, 2013    Free full text    Clinical Article

13 A comparison of different oral therapies versus no treatment for erectile dysfunction in 196 radical nerve-sparing radical prostatectomy patients International Journal of Impotence Research: The Journal of Sexual Medicine, August 12, 2014    Clinical Article

14 Impact of family history on prostate cancer mortality in white men undergoing prostate specific antigen based screening The Journal of Urology, November 11, 2014    Clinical Article

15 Effect of surgical margin status after radical prostatectomy on health-related quality of life and illness perception in patients with prostate cancer Urologic Oncology: Seminars and Original Investigations, November 25, 2014    Clinical Article

16 Carbohydrate intake, glycemic index and prostate cancer risk The Prostate, November 26, 2014    Clinical Article

17 Depression, anxiety, antidepressant use, and cardiovascular disease among Hispanic men and women of different national backgrounds: results from the Hispanic Community Health Study/Study of Latinos Annals of Epidemiology , November 14, 2014    Clinical Article

18 Effect of anti-inflammatory treatment on depression, depressive symptoms, and adverse effects: A systematic review and meta-analysis of randomized clinical trials JAMA Psychiatry, October 21, 2014    Evidence Based Medicine    Clinical Article

19 A clinical randomized controlled trial of music therapy and progressive muscle relaxation training in female breast cancer patients after radical mastectomy: Results on depression, anxiety and length of hospital stay European Journal of Oncology Nursing , November 5, 2014    Clinical Article

20 Comparison of cognitive behavioral therapy and supportive psychotherapy for the treatment of depression following traumatic brain injury: a randomized controlled trial Journal of Head Trauma Rehabilitation, November 20, 2014    Clinical Article

Indexed Journals in Family Medicine: American Family Physician, Archives of Family Med, Annals of Family Medmore