Effect of the disclosure of MS diagnosis on anxiety, mood and quality of life of patients: a prospective study
International Journal of Clinical Practice,  Clinical Article

Mattarozzi K et al. – This first prospective study provides objective data showing that early disclosure of multiple sclerosis diagnosis improves both the patient's quality of life and psychological well–being. In addition, the results seem to suggest that clinically isolated syndrome disclosure does not lead to the same favourable effects.

Methods
  • Eligible participants were all patients referred for the first time to the Neurological Unit who had manifested symptoms suggestive of MS for no more than 6 months.
  • All patients were evaluated for
    • QoL (SEIQoL and MS-QoL54).
    • Anxiety (STAI) and Depression (CMDI) on study inclusion (T0), 30 days after diagnosis disclosure (T30), and after 1 (T1y) and 2 (T2y) years' follow-up.

Results
  • Two hundred and twenty-nine patients were enrolled; 93 of these were unaware of their diagnosis.
  • Patients who already knew their diagnosis (100 with CIS and 22 with MS) were excluded from the main analyses and used to perform control analyses.
  • At the end of the screening, an MS diagnosis was disclosed to 18 of the 93 patients, whereas a CIS diagnosis was disclosed to 62 patients (12 patients received a diagnosis other than MS or CIS).
  • Thirty days after diagnosis disclosure, irrespective of the diagnosis disclosed, both QoL and Anxiety and Depression were significantly rated as better compared to the start of screening, (ps < 0.03), and this improvement remained stable over the two annual follow-ups.
  • However, as suggested by a significant `Time' × `Diagnosis' interaction with regard to both QoL and Anxiety and Depression (ps < 0.02), the effect of the disclosure in the short term differed depending on CIS or MS diagnosis.
  • Specifically, on MSQoL, which is a health-related QoL scale, the authors found a statically significant improvement, immediately after the diagnosis disclosure, in both the MS and CIS groups (ps < 0.01).
  • Differently, on SEIQoL, which is a non health-related QoL measure, and on the anxiety scale, the authors observed a statistically significant improvement only in the group which received a MS diagnosis (ps < 0.03).

Please login or register to follow this author.
Are you sure you want to Unfollow this Author?
► Click here to access PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

Your Unread Messages in Family Medicine

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Family Medicine Articles

1 A comparison of the effects of hatha yoga and resistance exercise on mental health and well-being in sedentary adults: A pilot study Complementary Therapies in Medicine, June 11, 2014    Clinical Article

2 Short-term effects of a manual therapy protocol on pain, physical function, quality of sleep, depressive symptoms, and pressure sensitivity in women and men with fibromyalgia syndrome: A randomized controlled trial The Clinical Journal of Pain, June 9, 2014    Clinical Article

3 Depression treatment by withdrawal of short-term low-dose antipsychotic, a proof-of-concept randomized double-blind study Journal of Affective Disorders, June 16, 2014    Clinical Article

4 Benefits and harms in clinical trials of duloxetine for treatment of major depressive disorder: comparison of clinical study reports, trial registries, and publications BMJ, June 12, 2014    Clinical Article

5 A comparison of the effects of hatha yoga and resistance exercise on mental health and well-being in sedentary adults: A pilot study Complementary Therapies in Medicine, June 19, 2014    Clinical Article

6 The effect of green tea on blood pressure and lipid profile: A systematic review and meta-analysis of randomized clinical trials Nutrition, Metabolism & Cardiovascular Diseases, March 27, 2014    Evidence Based Medicine    Review Article

7 Risk of myocardial infarction and stroke in bipolar disorder: A systematic review and exploratory meta-analysis Acta Psychiatrica Scandinavica, May 30, 2014    Evidence Based Medicine    Review Article

8 Impact of mindfulness-based cognitive therapy on health care utilization: a population-based controlled comparison Journal of Psychosomatic Research, June 26, 2014    Clinical Article

9 Prognostic impact of the serum heart-type fatty acid-binding protein (H-FABP) levels in patients admitted to the non-surgical intensive care unit Clinical Research in Cardiology, May 23, 2014    Clinical Article

10 Effect of dietary restriction on peripheral monoamines and anxiety symptoms in obese subjects with metabolic syndrome Psychoneuroendocrinology, June 24, 2014    Clinical Article

11 Efficacy and safety of olanzapine/fluoxetine combination vs fluoxetine monotherapy following successful combination therapy of treatment-resistant major depressive disorder Neuropsychopharmacology, June 2, 2014    Clinical Article

12 Duloxetine-bupropion combination for treatment-resistant atypical depression: A double-blind, randomized, placebo-controlled trial European Neuropsychopharmacology, May 22, 2014    Clinical Article

13 The association of internet addiction symptoms with anxiety, depression and self-esteem among adolescents with attention-deficit/hyperactivity disorder Comprehensive Psychiatry, June 17, 2014    Clinical Article

14 The impact of anxious symptoms in the remission of depressive symptoms in a clinical trial for depression: Follow-up of six months Journal of Affective Disorders, June 10, 2014    Clinical Article

15 Pharmacological and non-pharmacological interventions to improve cognitive dysfunction and functional ability in clinical depression – A systematic review Psychiatry Research, June 18, 2014    Evidence Based Medicine    Review Article

16 Efficacy and tolerability of antidepressants for sub-threshold depression and for mild major depressive disorder Journal of Affective Disorders, June 16, 2014    Evidence Based Medicine    Review Article

17 Changes in circulating leptin levels during acute stress and associations with craving in abstinent smokers: A preliminary investigation Psychoneuroendocrinology, June 20, 2014    Clinical Article

18 Individual mindfulness-based cognitive therapy (MBCT) and cognitive behavior therapy (CBT) for treating depressive symptoms in patients with diabetes: Results of a randomized controlled trial Diabetes Care, June 6, 2014    Clinical Article

19 Depression with atypical features and increase in obesity, body mass index, waist circumference, and fat mass : a prospective, population-based study JAMA Psychiatry, June 13, 2014    Clinical Article

20 Self-relevant disgust and self-harm urges in patients with borderline personality disorder and depression: A pilot study with a newly designed psychological challenge PLOS ONE, June 27, 2014    Clinical Article

Indexed Journals in Family Medicine: American Family Physician, Archives of Family Med, Annals of Family Medmore

Register now to view all the MDLinx contents (FREE)!

  • Stay current on the latest literature, research and clinical news
  • Get special communications and offers from MDLinx and our sponsors
  • Receive invitations to paid market research
View Samples and Register

Connect with us, stay current.

Receive the latest mecial news
updates for free via email

Sign up!

Subscribe to our free RSS feeds:

Get the latest news in your specialty automatically added to your newsreader or your personal My Yahoo!, Google, My MSN or My AOL page. Learn More

Close