The temporal impact of chronic intermittent psychosocial stress on high-fat diet-induced alterations in body weight
Finger BC et al. – The study describes the evolution of the chronic effects of social defeat/overcrowding stress in combination with exposure to high– or low–fat diet. Most importantly, the authors demonstrate that a six week chronic exposure to social defeat stress prevents the metabolic effects of high–fat diet, by inhibiting an increase in weight gain, caloric intake and efficiency and insulin resistance as well as in plasma leptin and insulin levels. This study highlights the importance of considering the chronic aspects of both parameters and their time–dependent interplay.