Prediction of primary vs secondary hypertension in children

The Journal of Clinical Hypertension, 04/27/2012

Abnormal renal ultrasound findings and age were predictors of secondary hypertension by regression and likelihood function analysis. Children aged 5 to 12 years with abnormal renal ultrasound findings and high diastolic blood pressures are at higher risk for secondary hypertension that requires detailed evaluation.

Methods

  • The study evaluates primary vs secondary hypertension diagnosis from investigations routinely performed in hypertensive children.
  • This retrospective study included children 5 to 19 years with primary and secondary hypertension.
  • The proportions of abnormal laboratory and imaging tests were compared between primary and secondary hypertension groups.
  • Risk factors for primary vs secondary hypertension were evaluated by logistic regression and likelihood function analysis.
  • Patients with secondary hypertension were younger (5–12 years) and had a higher proportion of abnormal creatinine, renal ultrasound, and echocardiogram findings.

Results

  • There was no significant difference in abnormal results of thyroid function, urine catecholamines, plasma renin, and aldosterone.
  • Abnormal renal ultrasound findings and age were predictors of secondary hypertension by regression and likelihood function analysis.

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