Microembolic signals and aspirin resistance in patients with carotid stenosis
Cardiovascular Therapeutics,  Clinical Article

Dawson J et al. – Aspirin resistance appears more common in patients with carotid disease who have microembolic signals (MES) compared to those without. Further work should aim to establish whether screening for aspirin resistance and subsequent adjustment to antiplatelet therapy reduces the rate of MES and stroke risk in those with carotid disease.

  • Authors studied patients with significant ICA disease who were compliant with aspirin therapy.
  • They performed monitoring for MES and measured aspirin resistance status, using the platelet function analyzer (PFA)–100 and Verify–Now systems.
  • They compared frequency of aspirin resistance between patients with and without MES and assessed agreement between the different platelet function tests.

  • Authors recruited 62 patients. Most (53, 85.5%) had symptomatic carotid disease and 16 (25.8%) had MES.
  • The rate of aspirin resistance on at least one test was 25.8% (16 patients), with 13 (21%) resistant on PFA–100 testing, 8 (12.9%) using the Verify–Now system and 5 (8.1%) resistant on both.
  • Aspirin resistance was more common in patients with MES (50% compared to 17.4% without, P= 0.018 on Fisher's exact test).
  • Agreement between the platelet function tests was moderate (κ= 0.41).

Please login or register to follow this author.
► Click here to access PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

    Currently, there are no available articles.

Your Unread Messages in Family Medicine

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Family Medicine Articles

Indexed Journals in Family Medicine: American Family Physician, Archives of Family Med, Annals of Family Medmore