Concomitant use of clopidogrel and statins and risk of major adverse cardiovascular events following coronary stent implantation
British Journal of Clinical Pharmacology,  Clinical Article

Schmidt M et al. – Clopidogrel and CYP3A4–metabolizing statin use were each associated with a substantially reduced rate of major adverse cardiovascular events (MACE) within 12 months after coronary stent implantation. Although authors observed an interaction between use of clopidogrel and statins, statin use vs. nonuse was not associated with an increased rate of MACE in patients using clopidogrel after coronary stent implantation.

Methods
  • Authors conducted this population–based cohort study in Western Denmark (population: 3 million) using medical databases.
  • They identified all 13,001 patients with coronary stent implantation between 2002 and 2005 and their comorbidities.
  • During 12–month follow–up, they tracked the use of clopidogrel and CYP3A4–metabolizing statins and the rate of MACE.
  • They used Cox regression to compute hazard ratios (HRs) controlling for potential confounders.

Results
  • The rate of MACE per 1000 person years was 104 for concomitant clopidogrel and statin use, 130 for clopidogrel without statin use, 108 for statin without clopidogrel use, and 446 for no use of either drug.
  • The adjusted HR comparing clopidogrel use with non–use was 0.68 (95% confidence interval (CI): 0.58–0.79) among statin users and 0.34 (95% CI: 0.29–0.40) among statin non–users, yielding an interaction effect (i.e., relative rate increase) of 1.97 (95% CI: 1.59–2.44).
  • The adjusted HR for MACE comparing statin use with non–use was 0.97 (95% CI: 0.83–1.13) among clopidogrel users and 0.49 (95% CI: 0.42–0.57) among clopidogrel non–users.

Please login or register to follow this author.
Are you sure you want to Unfollow this Author?
► Click here to access PubMed, Publisher and related articles...
<< Previous Article | Next Article >>

Your Unread Messages in Family Medicine

See All >> Messages include industry-sponsored communications and special communications from MDLinx

Most Popular Family Medicine Articles

1 A comparison of different oral therapies versus no treatment for erectile dysfunction in 196 radical nerve-sparing radical prostatectomy patients International Journal of Impotence Research: The Journal of Sexual Medicine, August 12, 2014    Clinical Article

2 Plasma tocopherols and risk of prostate cancer in the selenium and vitamin E cancer prevention trial (SELECT) Cancer Prevention Research, August 25, 2014    Clinical Article

3 Adjuvant radiotherapy versus wait-and-see after radical prostatectomy: 10-year follow-up of the ARO 96–02/AUO AP 09/95 Trial Full Text European Urology, July 18, 2014    Free full text    Clinical Article

4 Metformin in chemotherapy-naive castration-resistant prostate cancer: A multicenter phase 2 trial (SAKK 08/09) Full Text European Urology, August 15, 2014    Free full text    Clinical Article

5 Obesity is a risk factor for significant carotid atherosclerosis in patients aged 39 to 55 years Angiology, July 18, 2014    Evidence Based Medicine    Clinical Article

6 Management of prostate cancer in older patients: updated recommendations of a working group of the International Society of Geriatric Oncology The Lancet Oncology, July 30, 2014    Clinical Article

7 Circumcision plus antibiotic, anti-inflammatory, and α-blocker therapy for the treatment for chronic prostatitis/chronic pelvic pain syndrome: A prospective, randomized, multicenter trial World Journal of Urology, July 16, 2014    Clinical Article

8 Effect of caffeine on exercise capacity and function in prostate cancer survivors Medicine and Science in Sports and Exercise, July 9, 2014    Clinical Article

9 Urinating standing versus sitting: Position is of influence in men with prostate enlargement. A systematic review and meta-analysis PLOS ONE, August 1, 2014    Evidence Based Medicine    Review Article
Exclusive Author Commentary

10 Curcumin for the treatment of major depression: A randomised, double-blind, placebo controlled study Journal of Affective Disorders, July 16, 2014    Clinical Article

11 National trends in the management of low- and intermediate-risk prostate cancer in the United States The Journal of Urology, August 13, 2014    Clinical Article

12 Changes in circulating leptin levels during acute stress and associations with craving in abstinent smokers: A preliminary investigation Psychoneuroendocrinology, June 20, 2014    Clinical Article

13 Screening for prostate cancer in the US? Reduce the harms and keep the benefit International Journal of Cancer, August 15, 2014    Clinical Article

14 Effects of medical therapy or surgery on prostatic and bladder resistive indices in patients with benign prostatic hyperplasia Urologia Internationalis, August 19, 2014    Clinical Article

15 Management options for the treatment of benign prostatic hyperplasia with or without erectile dysfunction: a focus on tadalafil and patient considerations Full Text International Journal of General Medicine, August 12, 2014    Free full text    Review Article

16 Effects of tadalafil once daily or on demand versus placebo on time to recovery of erectile function in patients after bilateral nerve-sparing radical prostatectomy World Journal of Urology, August 27, 2014    Clinical Article

17 Cost-effectiveness of magnetic resonance (MR) imaging and MR-guided targeted biopsy versus systematic transrectal ultrasound–guided biopsy in diagnosing prostate cancer: A modelling study from a health care perspective Full Text European Urology, August 18, 2014    Free full text    Clinical Article

18 Radiation-induced secondary malignancy in prostate cancer: A systematic review and meta-analysis Urologia Internationalis, August 19, 2014    Evidence Based Medicine    Review Article

19 Efficacy of vilazodone on anxiety symptoms in patients with major depressive disorder International Clinical Psychopharmacology, July 2, 2014    Clinical Article

20 A population-based nested case-control study: the use of 5-alpha-reductase inhibitors and the increased risk of osteoporosis diagnosis in patients with benign prostate hyperplasia Clinical Endocrinology, August 28, 2014    Clinical Article

Indexed Journals in Family Medicine: American Family Physician, Archives of Family Med, Annals of Family Medmore

Register now to view all the MDLinx contents (FREE)!

  • Stay current on the latest literature, research and clinical news
  • Get special communications and offers from MDLinx and our sponsors
  • Receive invitations to paid market research
View Samples and Register

Connect with us, stay current.

Receive the latest mecial news
updates for free via email

Sign up!

Subscribe to our free RSS feeds:

Get the latest news in your specialty automatically added to your newsreader or your personal My Yahoo!, Google, My MSN or My AOL page. Learn More

Close